QuickView for DRD3 (gene)
- Gene Symbol:
- DRD3
Homo sapiens - Full name:
- dopamine receptor D3
- Synonyms:
- D3DR, ETM1, FET1, D(3) dopamine receptor, essential tremor 1
- Genomic Location:
- Chr 3: 115330247-115380589
- Description:
-
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associa...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
3q13.31
| Transcripts Names |
|---|
| NM_000796 |
| NM_033663 |
| NM_033658 |
| NM_033659 |
| NM_033660 |
| XM_017005829 |
| NM_001290809 |
| NM_001282563 |
GO Molecular Function
neurotransmitter receptor activity | cation binding | D1 dopamine receptor binding | transmembrane signaling receptor activity | G-protein coupled receptor activity | dopamine binding | signaling receptor binding | G-protein coupled amine receptor activity | protein domain specific binding | adrenergic receptor activity | dopamine receptor binding | signaling receptor activity | ion binding | organic cyclic compound binding | protein binding | dopamine neurotransmitter receptor activity | G-protein coupled receptor binding | drug binding | dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO Biological Process
negative regulation of G-protein coupled receptor protein signaling pathway | multicellular organismal movement | long-chain fatty acid transport | response to radiation | regulation of cell cycle process | reflex | positive regulation of macromolecule biosynthetic process | regulation of systemic arterial blood pressure by hormone | positive regulation of cellular component organization | regulation of neurogenesis | regulation of sodium ion transmembrane transporter activity | regulation of cellular localization | negative regulation of peptide secretion | intracellular signal transduction | regulation of cell development | regulation of localization | catechol-containing compound metabolic process | response to isoquinoline alkaloid | lipid transport | regulation of programmed cell death | regulation of sodium ion transport | establishment of localization | negative regulation of cellular process | social behavior | negative regulation of RNA biosynthetic process | cell differentiation | nervous system development | response to drug | cellular chemical homeostasis | neurogenesis | negative regulation of protein secretion | prepulse inhibition | regulation of organelle organization | regulation of renal sodium excretion | generation of neurons | response to antibiotic | phenol-containing compound metabolic process | regulation of circadian sleep/wake cycle | positive regulation of cellular biosynthetic process | cellular process | negative regulation of gliogenesis | secretion | regulation of catecholamine secretion | response to morphine | musculoskeletal movement | monocarboxylic acid transport | circadian regulation of gene expression | localization | cellular homeostasis | regulation of sodium ion transmembrane transport | negative regulation of signaling | visual learning | chemical synaptic transmission | regulation of mitotic nuclear division | anion transport | negative regulation of nucleic acid-templated transcription | learning | macromolecule localization | negative regulation of apoptotic process | negative regulation of secretion | regulation of cell cycle | regulation of multicellular organism growth | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of behavior | negative regulation of dopamine receptor signaling pathway | regulation of cell differentiation | positive regulation of cytokinesis | regulation of protein kinase B signaling | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | G-protein coupled receptor internalization | organic cyclic compound metabolic process | positive regulation of dopamine receptor signaling pathway | positive regulation of renal sodium excretion | cellular aromatic compound metabolic process | regulation of systemic arterial blood pressure mediated by a chemical signal | calcium ion homeostasis | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | regulation of cell division | G-protein coupled receptor activity | regulation of peptide secretion | associative learning | response to stimulus | negative regulation of protein transport | acid secretion | regulation of excretion | response to cocaine | adenylate cyclase-activating adrenergic receptor signaling pathway | regulation of response to drug | regulation of cell proliferation | gastric emptying | circadian rhythm | G-protein coupled amine receptor activity | negative regulation of transporter activity | response to alcohol | regulation of neurotransmitter uptake | rhythmic process | negative regulation of transport | regulation of protein transport | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of peptide transport | modulation of chemical synaptic transmission | cell-cell signaling | synaptic transmission, dopaminergic | regulation of oligodendrocyte differentiation | dopamine metabolic process | negative regulation of transmembrane transport | metal ion homeostasis | negative regulation of blood pressure | response to ethanol | regulation of nucleic acid-templated transcription | regulation of neurotransmitter levels | organic hydroxy compound metabolic process | response to nitrogen compound | response to light stimulus | regulation of proton transport | system development | adrenergic receptor activity | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of secretion by cell | multicellular organism development | learning or memory | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | negative regulation of sodium ion transmembrane transporter activity | arachidonic acid secretion | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | fatty acid transport | positive regulation of secretion | organic substance transport | nervous system process | regulation of blood pressure | synaptic signaling | regulation of sodium:proton antiporter activity | regulation of systemic arterial blood pressure by renin-angiotensin | regulation of systemic arterial blood pressure | positive regulation of cellular metabolic process | digestive system process | cellular ion homeostasis | regulation of dopamine receptor signaling pathway | regulation of dopamine uptake involved in synaptic transmission | response to ammonium ion | regulation of locomotion involved in locomotory behavior | regulation of nitrogen compound metabolic process | vesicle-mediated transport | regulation of transcription by RNA polymerase II | organic acid transport | regulation of synaptic transmission, dopaminergic | behavioral response to cocaine | second-messenger-mediated signaling | cognition | negative regulation of ion transmembrane transport | negative regulation of protein kinase B signaling | locomotory behavior | organic anion transport | regulation of blood volume by renin-angiotensin | negative regulation of ion transport | startle response | response to toxic substance | response to xenobiotic stimulus | regulation of circadian sleep/wake cycle, sleep | cation homeostasis | autophagy | dopamine receptor signaling pathway | cellular cation homeostasis | endocrine process | cell communication | regulation of cellular metabolic process | regulation of cytokinesis | receptor internalization | cyclic-nucleotide-mediated signaling | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of locomotion | regulation of RNA metabolic process | positive regulation of transport | response to histamine | regulation of dopamine secretion | regulation of mitotic cell cycle | drug metabolic process | negative adaptation of signaling pathway | regulation of establishment of protein localization | regulation of growth | response to organic substance | visual behavior | cAMP-mediated signaling | musculoskeletal movement, spinal reflex action | catecholamine metabolic process | import into cell | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | response to amine | metabolic process | lipid localization | dopamine neurotransmitter receptor activity | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | chemical homeostasis | endocytosis | regulation of secretion | negative regulation of sodium:proton antiporter activity | behavior | negative regulation of ion transmembrane transporter activity | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of protein secretion | positive regulation of G-protein coupled receptor protein signaling pathway | negative regulation of sodium ion transmembrane transport | desensitization of G-protein coupled receptor protein signaling pathway | ion homeostasis | response to alkaloid | regulation of ion transmembrane transport | adult behavior | regulation of glial cell differentiation | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | adenylate cyclase-inhibiting dopamine receptor signaling pathway | regulation of cell communication | regulation of gliogenesis | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | neuromuscular process | regulation of developmental growth | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | carboxylic acid transport | regulation of circadian rhythm | regulation of nervous system development | regulation of developmental process | regulation of ion transport | receptor-mediated endocytosis | regulation of G-protein coupled receptor protein signaling pathway | developmental process | positive regulation of cell cycle process | negative regulation of glial cell differentiation | digestion | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | adrenergic receptor signaling pathway | dopamine neurotransmitter receptor activity, coupled via Gi/Go | receptor metabolic process | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | cellular metal ion homeostasis | positive regulation of transcription by RNA polymerase II | response to anesthetic | gastric motility | regulation of lipid metabolic process | positive regulation of metabolic process | negative regulation of sodium ion transport | response to amphetamine | ion transport | adenylate cyclase-activating dopamine receptor signaling pathway | cellular metabolic process | regulation of protein localization | regulation of cell death | negative regulation of oligodendrocyte differentiation | negative regulation of cell death | negative regulation of cell development | divalent inorganic cation homeostasis | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of signaling | positive regulation of mitotic nuclear division | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process
GO Cellular Component
integral component of membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | apical part of cell | cell projection | plasma membrane | vesicle | integral component of plasma membrane | membrane-bounded organelle | organelle | cell periphery | intracellular vesicle | endocytic vesicle | intracellular | membrane | intrinsic component of plasma membrane
