QuickView for DTNA;jsessionid=D87E61D0A3E928EABCB376F381FBCDD2 (gene)

Gene Symbol:

DTNA Homo sapiens

Full name:

dystrobrevin alpha

Synonyms:

D18S892E, DRP3, DTN, DTN-A, LVNC1, dystrobrevin alpha, dystrophin-related protein 3

Genomic Location:

Chr 18: 30327279-30725364

Description:

The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The ...

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The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  FOXO1_02 ,  PR_Q2 ,  POU6F1_01 ,  OCT1_07 ,  RTAAACA_FREAC2_01 ,  OCT1_05 ,  GTGCCAT_MIR183 ,  FREAC7_01 ,  TTTGCAC_MIR19A_MIR19B ,  AP1_C ,  TGANTCA_AP1_C ,  AGTTCTC_MIR146A_MIR146B ,  AAGCCAT_MIR135A_MIR135B ,  OCT1_04 ,  AREB6_02 ,  TGANNYRGCA_TCF11MAFG_01 ,  AP3_Q6 ,  YTATTTTNR_MEF2_02 ,  CACGTG_MYC_Q2 ,  GCAAGGA_MIR502 ,  AAAYWAACM_HFH4_01 ,  FOXD3_01 ,  CTTTGCA_MIR527 ,  HFH1_01 ,  CAGCACT_MIR5123P ,  AP1_Q6 ,  CTTTGA_LEF1_Q2 ,  GGGCATT_MIR365 ,  OCT_C ,  ACTGTGA_MIR27A_MIR27B ,  CEBPDELTA_Q6 ,  OCT1_Q6 ,  NFE2_01 ,  TGTATGA_MIR4853P ,  AP1_Q6_01 ,  GCTTGAA_MIR498 ,  FOXO3_01 ,  FREAC3_01 ,  P53_02 ,  RFX1_02 ,  CDX2_Q5 ,  AP1_01 ,  GTCAGGA_MIR378 ,  CAGCTTT_MIR320 ,  NKX62_Q2 ,  TGCCTTA_MIR124A ,  ACCAAAG_MIR9 ,  FOXJ2_01 ,  TGCTGAY_UNKNOWN ,  NKX61_01 ,  CTCTGGA_MIR520A_MIR525 ,  FOXO1_01 ,  HFH8_01 ,  SOX5_01 ,  RORA1_01 ,  OCT1_02 ,  FREAC2_01 ,  TTGTTT_FOXO4_01 ,  ATATGCA_MIR448 ,  AFP1_Q6 ,  GTTATAT_MIR410 ,  GTGGGTGK_UNKNOWN ,  RORA2_01 ,  CTCTAGA_MIR526C_MIR518F_MIR526A ,  TGATTTRY_GFI1_01 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  CACBINDINGPROTEIN_Q6 ,  SRY_02 ,  AAACCAC_MIR140 ,  AACTTT_UNKNOWN ,  TCATCTC_MIR143 ,  PAX2_02 ,  AP1_Q4_01 ,  GTTRYCATRR_UNKNOWN ,  FOXO4_02 ,  GGGTGGRR_PAX4_03 ,  TGASTMAGC_NFE2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-146 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-378

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Cytogenetic Map:

18q12.1

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