QuickView for DUSP10 (gene)

Gene Symbol:

DUSP10 Homo sapiens

Full name:

dual specificity phosphatase 10

Synonyms:

MKP-5, MKP5, dual specificity protein phosphatase 10, dual specificity phosphatase MKP-5, map kinase phosphatase 5, mitogen-activated protein kinase phosphatase 5, serine/threonine specific protein phosphatase

Genomic Location:

Chr 1: 219941389-219982084

Description:

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatas...

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Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  IRF1_01 ,  PBX1_02 ,  RTAAACA_FREAC2_01 ,  GTGCCAT_MIR183 ,  PR_02 ,  TAL1ALPHAE47_01 ,  CGCAAAA_MIR450 ,  YATGNWAAT_OCT_C ,  YTATTTTNR_MEF2_02 ,  SRF_Q6 ,  AACTGAC_MIR223 ,  NFY_C ,  HP1SITEFACTOR_Q6 ,  TAAYNRNNTCC_UNKNOWN ,  CTTTGA_LEF1_Q2 ,  PBX1_01 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  WTGAAAT_UNKNOWN ,  TGAYRTCA_ATF3_Q6 ,  TAL1BETAE47_01 ,  CDP_02 ,  LEF1_Q2 ,  GGATTA_PITX2_Q2 ,  YY1_01 ,  NF1_Q6 ,  GCAAAAA_MIR129 ,  ATF3_Q6 ,  PITX2_Q2 ,  YKACATTT_UNKNOWN ,  IRF_Q6 ,  CTTTAAR_UNKNOWN ,  E47_01 ,  NF1_Q6_01 ,  TGTTTGY_HNF3_Q6 ,  OCT1_06 ,  GR_01 ,  ARGGGTTAA_UNKNOWN ,  TAL1BETAITF2_01 ,  SRF_Q5_01 ,  TCCATTKW_UNKNOWN ,  ICSBP_Q6 ,  YRCCAKNNGNCGC_UNKNOWN ,  ISRE_01 ,  BRN2_01 ,  AACTTT_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  TGACATY_UNKNOWN ,  DR4_Q2 ,  TCF1P_Q6 ,  SRF_C ,  IRF2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-410

Cytogenetic Map:

1q41

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