QuickView for Dab2ip (gene)
- Gene Symbol:
- DAB2IP
Homo sapiens - Full name:
- DAB2 interacting protein
- Synonyms:
- AF9Q34, AIP-1, AIP1, DIP1/2, disabled homolog 2-interacting protein, ASK-interacting protein 1, ASK1-interacting protein 1, DAB2 interaction protein, DOC-2/DAB2 interactive protein, nGAP-like protein
- Genomic Location:
- Chr 9: 123369220-123587630
- Description:
-
DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-129 , Predicted Gene Targets for miR-185 , Predicted Gene Targets for miR-25 , Predicted Gene Targets for miR-338 , Predicted Gene Targets for miR-34 , Predicted Gene Targets for miR-431 , Predicted Gene Targets for miR-450 , Predicted Gene Targets for miR-96 , Predicted Gene Targets for miR-137 , Predicted Gene Targets for miR-182
- Cytogenetic Map:
-
9q33.2
GO Molecular Function
phosphatidylinositol 3-kinase binding | kinase binding | protein phosphatase 2A binding | cadherin binding | 14-3-3 protein binding | protein kinase binding | enzyme binding | protein-containing complex binding | lipid binding | SH3 domain binding | signaling receptor binding | cytokine receptor binding | Toll-like receptor binding | phospholipid binding | signaling adaptor activity | protein domain specific binding | phosphatidylinositol-3-phosphate binding | anion binding | death receptor binding | phosphatidylinositol 3-kinase regulatory subunit binding | Toll-like receptor 4 binding | mitogen-activated protein kinase kinase binding | identical protein binding | vascular endothelial growth factor receptor binding | ion binding | molecular adaptor activity | cell adhesion molecule binding | mitogen-activated protein kinase kinase kinase binding | vascular endothelial growth factor receptor 2 binding | protein binding | protein homodimerization activity | protein phosphatase binding | protein dimerization activity | phosphatidylinositol binding | phosphatidylinositol-4-phosphate binding | growth factor receptor binding | phosphatase binding | tumor necrosis factor receptor superfamily binding | phosphatidylinositol phosphate binding
GO Biological Process
positive regulation of endoplasmic reticulum unfolded protein response | regulation of JUN kinase activity | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | brain development | negative regulation of phosphatidylinositol 3-kinase signaling | cell morphogenesis | regulation of IRE1-mediated unfolded protein response | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | negative regulation of MAPK cascade | negative regulation of immune system process | positive regulation of IRE1-mediated unfolded protein response | response to endoplasmic reticulum stress | response to cytokine | response to interleukin-1 | positive regulation of cellular component organization | cell motility | regulation of neurogenesis | neuron projection morphogenesis | response to lipopolysaccharide | regulation of endoplasmic reticulum unfolded protein response | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | regulation of localization | regulation of programmed cell death | epithelial cell apoptotic process | regulation of immune system process | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | regulation of MAP kinase activity | negative regulation of RNA biosynthetic process | cellular response to tumor necrosis factor | cell differentiation | defense response | nervous system development | positive regulation of protein catabolic process | negative regulation of protein phosphorylation | cell part morphogenesis | neurogenesis | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | generation of neurons | negative regulation of toll-like receptor 4 signaling pathway | regulation of toll-like receptor 4 signaling pathway | blood vessel morphogenesis | positive regulation of GTPase activity | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | regulation of neuron migration | regulation of cell motility | localization | cell projection morphogenesis | extrinsic apoptotic signaling pathway | forebrain cell migration | negative regulation of signaling | neuron development | regulation of vascular endothelial growth factor receptor signaling pathway | I-kappaB phosphorylation | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | regulation of proteolysis | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | regulation of neuron projection development | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | regulation of binding | negative regulation of lipid kinase activity | regulation of cell differentiation | intrinsic apoptotic signaling pathway | negative regulation of cell motility | regulation of angiogenesis | regulation of immune response | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | gliogenesis | positive regulation of stress-activated MAPK cascade | catabolic process | regulation of protein complex assembly | cellular response to molecule of bacterial origin | positive regulation of cellular protein metabolic process | cellular response to unfolded protein | response to topologically incorrect protein | negative regulation of epidermal growth factor receptor signaling pathway | cellular component organization | MAPK cascade | cellular response to topologically incorrect protein | negative regulation of toll-like receptor signaling pathway | negative regulation of cellular protein catabolic process | head development | positive regulation of cellular protein catabolic process | regulation of vascular endothelial growth factor signaling pathway | positive regulation of stress-activated protein kinase signaling cascade | regulation of vasculature development | response to stimulus | negative regulation of vascular endothelial growth factor receptor signaling pathway | vasculature development | cellular response to vascular endothelial growth factor stimulus | negative regulation of epithelial to mesenchymal transition | JNK cascade | cerebral cortex radial glia guided migration | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | regulation of cellular protein catabolic process | response to stress | negative regulation of protein kinase activity | regulation of response to endoplasmic reticulum stress | regulation of cell proliferation | negative regulation of angiogenesis | tube morphogenesis | activation of MAPKKK activity | telencephalon cell migration | programmed cell death | positive regulation of proteolysis involved in cellular protein catabolic process | cellular protein catabolic process | cardiovascular system development | positive regulation of proteolysis | response to molecule of bacterial origin | extrinsic apoptotic signaling pathway via death domain receptors | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | protein modification process | regulation of synapse structure or activity | regulation of phosphatidylinositol 3-kinase activity | macromolecule modification | negative regulation of ERK1 and ERK2 cascade | activation of protein kinase activity | blood vessel development | stress-activated protein kinase signaling cascade | regulation of nucleic acid-templated transcription | negative regulation of NF-kappaB transcription factor activity | regulation of cellular response to stress | locomotion | apoptotic process | signaling adaptor activity | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | positive regulation of neuron projection development | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of toll-like receptor signaling pathway | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | telencephalon development | positive regulation of cell cycle | regulation of small GTPase mediated signal transduction | regulation of neuron differentiation | regulation of gene expression | cellular response to stress | response to lipid | cell cycle | protein catabolic process | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | endothelial cell apoptotic process | regulation of synapse maturation | regulation of synapse organization | regulation of nitrogen compound metabolic process | regulation of cell migration | glial cell migration | enzyme linked receptor protein signaling pathway | positive regulation of JNK cascade | positive regulation of cell projection organization | negative regulation of cellular response to growth factor stimulus | negative regulation of DNA-binding transcription factor activity | positive regulation of intracellular signal transduction | negative regulation of protein serine/threonine kinase activity | regulation of cellular component movement | regulation of transcription by RNA polymerase II | positive regulation of hydrolase activity | positive regulation of cell differentiation | regulation of endothelial cell migration | negative regulation of G0 to G1 transition | positive regulation of cell migration | cellular response to cytokine stimulus | negative regulation of epithelial cell migration | stress-activated MAPK cascade | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | angiogenesis | phosphorylation | regulation of GTPase activity | regulation of apoptotic signaling pathway | cerebral cortex cell migration | protein phosphorylation | negative regulation of cellular response to vascular endothelial growth factor stimulus | phosphate-containing compound metabolic process | response to bacterium | regulation of lipid kinase activity | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of synapse maturation | inflammatory response | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of locomotion | negative regulation of MAP kinase activity | regulation of RNA metabolic process | regulation of phospholipid metabolic process | cerebral cortex development | regulation of cellular response to growth factor stimulus | apoptotic signaling pathway | positive regulation of dendrite development | positive regulation of molecular function | vascular endothelial growth factor receptor-2 signaling pathway | cellular response to epidermal growth factor stimulus | positive regulation of cell cycle arrest | neuron differentiation | activation of MAPK activity | negative regulation of epithelial cell proliferation | protein metabolic process | regulation of fibroblast proliferation | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of innate immune response | regulation of kinase activity | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | anatomical structure development | regulation of protein heterodimerization activity | cell surface receptor signaling pathway | positive regulation of neurogenesis | negative regulation of lipid metabolic process | cell projection organization | metabolic process | positive regulation of cell development | negative regulation of I-kappaB kinase/NF-kappaB signaling | regulation of protein catabolic process | regulation of RNA biosynthetic process | reelin-mediated signaling pathway | negative regulation of transcription, DNA-templated | regulation of proteasomal protein catabolic process | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | positive regulation of cell death | immune response | negative regulation of ERBB signaling pathway | neuron projection development | positive regulation of neuron migration | organic substance metabolic process | regulation of epidermal growth factor receptor signaling pathway | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | cerebral cortex radially oriented cell migration | forebrain development | pallium development | negative regulation of vascular endothelial growth factor signaling pathway | negative regulation of cellular protein metabolic process | negative regulation of small GTPase mediated signal transduction | negative regulation of cellular component movement | negative regulation of Ras protein signal transduction | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of G0 to G1 transition | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | regulation of JNK cascade | positive regulation of MAPK cascade | response to epidermal growth factor | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | negative regulation of protein catabolic process | negative regulation of protein metabolic process | regulation of dendrite development | regulation of epithelial cell migration | organonitrogen compound catabolic process | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of protein binding | cell development | regulation of ERBB signaling pathway | I-kappaB kinase/NF-kappaB signaling | regulation of epithelial cell proliferation | negative regulation of fibroblast proliferation | positive regulation of phosphorylation | cellular protein metabolic process | response to unfolded protein | regulation of Ras protein signal transduction | anatomical structure morphogenesis | positive regulation of MAP kinase activity | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | developmental process | negative regulation of canonical Wnt signaling pathway | layer formation in cerebral cortex | cellular response to interleukin-1 | positive regulation of cell cycle process | cellular protein modification process | cell motility involved in cerebral cortex radial glia guided migration | vascular endothelial growth factor receptor signaling pathway | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | innate immune response | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | negative regulation of endothelial cell migration | negative regulation of GTPase activity | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | negative regulation of hydrolase activity | tube formation | positive regulation of JUN kinase activity | negative regulation of phosphatidylinositol 3-kinase activity | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of lipid metabolic process | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | positive regulation of neuron differentiation | regulation of cell projection organization | immune system process | cellular metabolic process | negative regulation of cell cycle process | response to tumor necrosis factor | cellular response to organic substance | regulation of cell death | activation of JUN kinase activity | positive regulation of cell motility | circulatory system development | negative regulation of locomotion | regulation of I-kappaB kinase/NF-kappaB signaling | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of apoptotic signaling pathway | response to other organism | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | regulation of p38MAPK cascade | positive regulation of gene expression | cellular response to growth factor stimulus | cellular response to lipopolysaccharide | macromolecule metabolic process | positive regulation of response to endoplasmic reticulum stress | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
climbing fiber | dendrite | neuron projection | somatodendritic compartment | cytoplasmic vesicle | cell body | cell | neuronal cell body | parallel fiber | cytoplasm | cerebellar mossy fiber | intracellular organelle | dendritic tree | protein-containing complex | cell projection | plasma membrane | vesicle | neuronal cell body membrane | AIP1-IRE1 complex | membrane-bounded organelle | organelle | cell periphery | cell body membrane | axon | cytosol | intracellular vesicle | endocytic vesicle | intracellular | membrane
