QuickView for Dlst (gene)
- Gene Symbol:
- DLST
Homo sapiens - Full name:
- dihydrolipoamide S-succinyltransferase
- Synonyms:
- DLTS, dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial, E2K, OGDC-E2, dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
- Genomic Location:
- Chr 14: 74418372-74440199
- Description:
-
This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
14q24.3
GO Molecular Function
transferase activity, transferring acyl groups other than amino-acyl groups | catalytic activity | transferase activity, transferring acyl groups | dihydrolipoyllysine-residue succinyltransferase activity | transferase activity
GO Biological Process
purine ribonucleotide metabolic process | tricarboxylic acid cycle | sulfur compound metabolic process | generation of precursor metabolites and energy | aerobic respiration | lysine catabolic process | cellular amino acid catabolic process | cellular process | organic substance catabolic process | dicarboxylic acid metabolic process | nucleotide metabolic process | cellular respiration | ribose phosphate metabolic process | ribonucleotide metabolic process | cellular amino acid metabolic process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | succinyl-CoA metabolic process | purine nucleotide metabolic process | carboxylic acid catabolic process | acetyl-CoA metabolic process | cellular nitrogen compound metabolic process | cofactor metabolic process | protein modification process | macromolecule modification | drug catabolic process | nitrogen compound metabolic process | antibiotic metabolic process | phosphorus metabolic process | acyl-CoA metabolic process | organophosphate metabolic process | small molecule metabolic process | cellular amide metabolic process | nucleobase-containing small molecule metabolic process | L-lysine catabolic process | phosphate-containing compound metabolic process | 2-oxoglutarate metabolic process | drug metabolic process | carboxylic acid metabolic process | protein metabolic process | tricarboxylic acid metabolic process | metabolic process | oxidation-reduction process | citrate metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | organonitrogen compound catabolic process | organic acid metabolic process | cellular protein metabolic process | energy derivation by oxidation of organic compounds | cellular protein modification process | carbohydrate derivative metabolic process | heterocycle metabolic process | L-lysine catabolic process to acetyl-CoA via saccharopine | cellular metabolic process | histone succinylation | macromolecule metabolic process
GO Cellular Component
mitochondrial matrix | intracellular membrane-bounded organelle | catalytic complex | cell | oxidoreductase complex | cytoplasm | oxoglutarate dehydrogenase complex | intracellular organelle | protein-containing complex | transferase complex | mitochondrion | membrane-bounded organelle | nucleus | organelle | tricarboxylic acid cycle enzyme complex | membrane-enclosed lumen | intracellular | myelin sheath | membrane
