QuickView for Dysadherin (gene)

Gene Symbol:

FXYD5 Homo sapiens

Full name:

FXYD domain containing ion transport regulator 5

Synonyms:

DYSAD, HSPC113, IWU1, KCT1, OIT2, PRO6241, RIC, FXYD domain-containing ion transport regulator 5, dysadherin, keratinocytes associated transmembrane protein 1

Genomic Location:

Chr 19: 40337467-40352625

Description:

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RI...

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This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

IRF1_01 ,  ETS_Q4 ,  RYTTCCTG_ETS2_B ,  TEL2_Q6 ,  NERF_Q2 ,  MGGAAGTG_GABP_B ,  RTTTNNNYTGGM_UNKNOWN ,  T3R_Q6 ,  TCF1P_Q6 ,  IRF2_01

Cytogenetic Map:

19q13.12

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