QuickView for E2F2;jsessionid=1F2F066480FE0B243AC75627AD3BB682 (gene)
- Gene Symbol:
- E2F2
Homo sapiens - Full name:
- E2F transcription factor 2
- Synonyms:
- E2F-2, transcription factor E2F2
- Genomic Location:
- Chr 1: 23705509-23730300
- Description:
-
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
1p36.12
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | intracellular signal transduction | epithelial cell apoptotic process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | regulation of sprouting angiogenesis | positive regulation of cellular biosynthetic process | cellular process | negative regulation of nucleic acid-templated transcription | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | intrinsic apoptotic signaling pathway | regulation of angiogenesis | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of vasculature development | response to stimulus | cellular nitrogen compound biosynthetic process | negative regulation of angiogenesis | programmed cell death | cellular nitrogen compound metabolic process | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | apoptotic process | nitrogen compound metabolic process | regulation of gene expression | cell cycle | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | biosynthetic process | lens fiber cell apoptotic process | aromatic compound biosynthetic process | cell communication | regulation of cellular metabolic process | regulation of RNA metabolic process | negative regulation of sprouting angiogenesis | apoptotic signaling pathway | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | intrinsic apoptotic signaling pathway by p53 class mediator | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | signaling | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | regulation of developmental process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | signal transduction by p53 class mediator | signal transduction | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
nuclear transcription factor complex | intracellular membrane-bounded organelle | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
