QuickView for EDAR;jsessionid=365CAA1329DA707C0C5B445E898B96CD (gene)

Gene Symbol:

EDAR Homo sapiens

Full name:

ectodysplasin A receptor

Synonyms:

DL, ECTD10A, ECTD10B, ED1R, ED3, ED5, EDA-A1R, EDA1R, EDA3, HRM1, tumor necrosis factor receptor superfamily member EDAR, EDA-A1 receptor, anhidrotic ectodysplasin receptor 1, downless homolog, downless, mouse, homolog of, ectodermal dysplasia receptor, ectodysplasin 1, anhidrotic receptor

Genomic Location:

Chr 2: 108877361-108972260

Description:

This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations ...

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This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CIZ_01 ,  ACTGTGA_MIR27A_MIR27B ,  CAGGTG_E12_Q6 ,  AGTCTTA_MIR499 ,  ATACTGT_MIR144 ,  TTGTTT_FOXO4_01 ,  CTTTGT_LEF1_Q2 ,  TATTATA_MIR374 ,  TCF11_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-499

Cytogenetic Map:

2q13

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