QuickView for EDN (gene)
- Gene Symbol:
- RNASE2
Homo sapiens - Full name:
- ribonuclease A family member 2
- Synonyms:
- EDN, RAF3, RNS2, non-secretory ribonuclease, RNase 2, RNase UpI-2, eosinophil-derived neurotoxin, ribonuclease 2, ribonuclease A F3, ribonuclease US, ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
- Genomic Location:
- Chr 14: 20493470-20494434
- Description:
-
The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses.
- Orthologs:
- Mus musculus , Rattus norvegicus , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
14q11.2
GO Molecular Function
nuclease activity | nucleic acid binding | lipid binding | hydrolase activity | carbohydrate derivative binding | ribonuclease activity | catalytic activity | ribonuclease A activity | endoribonuclease activity, producing 3'-phosphomonoesters | hydrolase activity, acting on ester bonds | organic cyclic compound binding | endoribonuclease activity | lipopolysaccharide binding | endonuclease activity | heterocyclic compound binding
GO Biological Process
RNA metabolic process | response to virus | exocytosis | neutrophil activation | nuclease activity | defense response to other organism | establishment of localization | defense response | defense response to Gram-negative bacterium | cellular process | secretion | organic substance catabolic process | leukocyte degranulation | localization | induction of bacterial agglutination | leukocyte activation | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to stimulus | neutrophil degranulation | response to stress | leukocyte activation involved in immune response | secretion by cell | cellular nitrogen compound metabolic process | nucleic acid phosphodiester bond hydrolysis | ribonuclease activity | nucleobase-containing compound catabolic process | ribonuclease A activity | locomotion | response to external biotic stimulus | nitrogen compound metabolic process | antibacterial humoral response | leukocyte mediated immunity | endoribonuclease activity, producing 3'-phosphomonoesters | RNA catabolic process | defense response to virus | vesicle-mediated transport | regulated exocytosis | response to bacterium | humoral immune response | cell activation involved in immune response | myeloid cell activation involved in immune response | aromatic compound catabolic process | neutrophil activation involved in immune response | defense response to bacterium | endoribonuclease activity | antimicrobial humoral response | cellular macromolecule catabolic process | metabolic process | RNA phosphodiester bond hydrolysis, endonucleolytic | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | RNA phosphodiester bond hydrolysis | endonuclease activity | cell activation | defense response to Gram-positive bacterium | response to biotic stimulus | neutrophil mediated immunity | heterocycle metabolic process | immune system process | cellular metabolic process | chemotaxis | response to other organism | macromolecule metabolic process
GO Cellular Component
secretory granule | azurophil granule lumen | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | vacuolar lumen | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | secretory vesicle | endomembrane system | vacuole | vesicle | extracellular exosome | lytic vacuole | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | lysosome | extracellular space | membrane-enclosed lumen | azurophil granule | secretory granule lumen | intracellular vesicle | intracellular | vesicle lumen
