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QuickView for EDNRA (gene)

Gene Symbol:
EDNRA Homo sapiens Homo sapiens
Full name:
endothelin receptor type A
ET-A, ETA, ETA-R, ETAR, ETRA, MFDA, hET-AR, endothelin-1 receptor, G protein-coupled receptor, endothelin receptor subtype A, endothelin-1-specific receptor
Genomic Location:
Chr 4: 148621575-148685555
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistan...
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 4

GO Molecular Function

phospholipase activity | transmembrane signaling receptor activity | G-protein coupled receptor activity | hydrolase activity | catalytic activity | signaling receptor activity | endothelin receptor activity | hydrolase activity, acting on ester bonds | lipase activity | protein binding | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | phosphatidylinositol phospholipase C activity | peptide receptor activity | G-protein coupled peptide receptor activity | phospholipase C activity

GO Biological Process

respiratory gaseous exchange | regulation of blood vessel diameter | regulation of localization | morphogenesis of an epithelium | vascular smooth muscle contraction | establishment of localization | cell differentiation | nervous system development | cellular chemical homeostasis | tonic smooth muscle contraction | mesenchyme development | blood vessel morphogenesis | artery smooth muscle contraction | cellular process | localization | cellular homeostasis | epithelial tube morphogenesis | response to hypoxia | positive regulation of catalytic activity | activation of phospholipase C activity | tissue development | autonomic nervous system development | regulation of cellular process | regulation of cytosolic calcium ion concentration | epithelium development | smooth muscle contraction | calcium ion homeostasis | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | head development | G-protein coupled receptor activity | muscle contraction | branching involved in blood vessel morphogenesis | response to stimulus | vasculature development | mesenchymal cell development | regulation of blood vessel size | response to stress | monosaccharide transmembrane transport | tube morphogenesis | cardiovascular system development | positive regulation of lipase activity | blood circulation | G-protein coupled receptor signaling pathway | embryo development | metal ion homeostasis | blood vessel development | negative regulation of blood vessel diameter | positive regulation of phospholipase C activity | system development | response to oxygen levels | multicellular organism development | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | regulation of catalytic activity | organic substance transport | regulation of blood pressure | cellular ion homeostasis | enteric nervous system development | positive regulation of cytosolic calcium ion concentration | endothelin receptor activity | hexose transmembrane transport | positive regulation of hydrolase activity | stem cell differentiation | cell proliferation | endothelin receptor signaling pathway | vasoconstriction | angiogenesis | regulation of phospholipase activity | cation homeostasis | chordate embryonic development | cellular cation homeostasis | cell communication | heart development | cellular calcium ion homeostasis | homeostatic process | embryo development ending in birth or egg hatching | regulation of tube size | carbohydrate transport | regulation of phospholipase C activity | carbohydrate transmembrane transport | positive regulation of molecular function | activation of adenylate cyclase activity | tissue morphogenesis | branching morphogenesis of an epithelial tube | anatomical structure development | mesenchymal cell differentiation | regulation of tube diameter | chemical homeostasis | regulation of glucose transmembrane transport | animal organ development | ion homeostasis | positive regulation of phospholipase activity | glucose transmembrane transport | stem cell development | morphogenesis of a branching epithelium | anatomical structure formation involved in morphogenesis | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | transmembrane transport | signaling | G-protein coupled peptide receptor activity | cell development | morphogenesis of a branching structure | anatomical structure morphogenesis | developmental process | tube development | regulation of transport | neural crest cell differentiation | cellular metal ion homeostasis | in utero embryonic development | circulatory system development | divalent inorganic cation homeostasis | neural crest cell development | muscle system process | signal transduction | multicellular organismal process

GO Cellular Component

integral component of membrane | cell | intrinsic component of membrane | plasma membrane | integral component of plasma membrane | cell periphery | membrane | intrinsic component of plasma membrane