QuickView for EDNRA (gene)

Gene Symbol:

EDNRA Homo sapiens

Full name:

endothelin receptor type A

Synonyms:

ET-A, ETA, ETA-R, ETAR, ETRA, MFDA, hET-AR, endothelin-1 receptor, G protein-coupled receptor, endothelin receptor subtype A, endothelin-1-specific receptor

Genomic Location:

Chr 4: 148621575-148685555

Description:

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistan...

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This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  AP3_Q6 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  ACTGTGA_MIR27A_MIR27B ,  CEBP_01 ,  CEBP_Q3 ,  BRN2_01 ,  GGCAGTG_MIR3243P

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-324-3p

Cytogenetic Map:

4q31.22-q31.23

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