QuickView for EGLN2 (gene)
- Gene Symbol:
- EGLN2
Homo sapiens - Full name:
- egl-9 family hypoxia inducible factor 2
- Synonyms:
- EIT6, HIF-PH1, HIFPH1, HPH-1, HPH-3, PHD1, egl nine homolog 2, HIF-prolyl hydroxylase 1, estrogen-induced tag 6, hypoxia-inducible factor prolyl hydroxylase 1, prolyl hydroxylase domain-containing protein 1
- Genomic Location:
- Chr 19: 45996888-46006177
- Description:
-
The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. R...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
NKX25_01 , SP1_01 , USF_Q6 , CCCAGAG_MIR326 , ARNT_01 , VDR_Q3 , YATGNWAAT_OCT_C , CACGTG_MYC_Q2 , NGFIC_01 , AP2GAMMA_01
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
19q13.2
GO Molecular Function
cofactor binding | cation binding | L-ascorbic acid binding | carboxylic acid binding | ferrous iron binding | vitamin binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | iron ion binding | coenzyme binding | peptidyl-proline dioxygenase activity | monosaccharide binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | anion binding | oxygen sensor activity | peptidyl-proline 4-dioxygenase activity | ion binding | carbohydrate binding | oxygen binding | protein binding | dioxygenase activity | transition metal ion binding | drug binding | organic acid binding | metal ion binding | oxidoreductase activity | small molecule binding
GO Biological Process
cellular response to decreased oxygen levels | regulation of programmed cell death | peptidyl-amino acid modification | response to hormone | positive regulation of protein catabolic process | hormone-mediated signaling pathway | regulation of neuron death | cellular process | cellular homeostasis | peptidyl-proline modification | response to hypoxia | positive regulation of nitrogen compound metabolic process | cellular amino acid metabolic process | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | response to stimulus | positive regulation of protein metabolic process | cellular response to hypoxia | response to stress | cell redox homeostasis | peptidyl-proline hydroxylation | cellular response to organic cyclic compound | peptidyl-proline dioxygenase activity | protein modification process | steroid hormone mediated signaling pathway | macromolecule modification | regulation of nucleic acid-templated transcription | cellular response to hormone stimulus | response to oxygen levels | nitrogen compound metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 4-hydroxyproline metabolic process | regulation of gene expression | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | cellular response to stress | response to lipid | peptidyl-proline 4-dioxygenase activity | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | intracellular estrogen receptor signaling pathway | small molecule metabolic process | regulation of transcription by RNA polymerase II | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | regulation of protein metabolic process | homeostatic process | regulation of RNA metabolic process | protein hydroxylation | carboxylic acid metabolic process | protein metabolic process | regulation of growth | response to organic substance | metabolic process | regulation of DNA-templated transcription in response to stress | regulation of protein catabolic process | regulation of RNA biosynthetic process | oxidation-reduction process | organic substance metabolic process | dioxygenase activity | cellular response to steroid hormone stimulus | intracellular receptor signaling pathway | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | organic acid metabolic process | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | regulation of transcription from RNA polymerase II promoter in response to hypoxia | regulation of cell growth | intracellular steroid hormone receptor signaling pathway | cellular protein modification process | cellular modified amino acid metabolic process | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | regulation of cell death | oxidoreductase activity | response to steroid hormone | regulation of cellular component organization | signal transduction | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
