QuickView for ELAC2 (gene)

Gene Symbol:

ELAC2 Homo sapiens

Full name:

elaC ribonuclease Z 2

Synonyms:

COXPD17, ELC2, HPC2, zinc phosphodiesterase ELAC protein 2, RNase Z 2, elaC homolog 2, elaC homolog protein 2, elaC-like protein 2, heredity prostate cancer protein 2, putative prostate cancer susceptibility protein HPC2/ELAC2, ribonuclease Z 2, tRNA 3 endonuclease 2, tRNase Z (long form), tRNase Z 2

Genomic Location:

Chr 17: 12836427-12862084

Description:

The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can su...

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The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  NFY_C ,  NFY_Q6_01 ,  GGGCGGR_SP1_Q6 ,  NFY_01 ,  NFY_Q6 ,  SP1_Q6_01 ,  GCTNWTTGK_UNKNOWN

Cytogenetic Map:

17p12

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