QuickView for EP300 (gene)

Gene Symbol:

EP300 Homo sapiens

Full name:

E1A binding protein p300

Synonyms:

KAT3B, RSTS2, p300, histone acetyltransferase p300, E1A-associated protein p300, E1A-binding protein, 300kD, histone butyryltransferase p300, histone crotonyltransferase p300, p300 HAT, protein propionyltransferase p300

Genomic Location:

Chr 22: 39818553-39906024

Description:

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CR...

View Full Description

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFMUE1_Q6 ,  GTATTAT_MIR3693P ,  TFIIA_Q6 ,  CEBPA_01 ,  STAT1_02 ,  P53_DECAMER_Q2 ,  SYATTGTG_UNKNOWN ,  ATTACAT_MIR3803P ,  E4BP4_01 ,  GCANCTGNY_MYOD_Q6 ,  TGTGTGA_MIR377 ,  STAT6_01 ,  ACTTTAT_MIR1425P ,  GR_Q6_01 ,  STAT1_03 ,  GTGCAAA_MIR507 ,  GCCATNTTG_YY1_Q6 ,  TTAYRTAA_E4BP4_01 ,  GGGAGGRR_MAZ_Q6 ,  GTGTGAG_MIR342 ,  CEBPB_01 ,  YY1_Q6 ,  YYCATTCAWW_UNKNOWN ,  RREB1_01 ,  CAGGTG_E12_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  TTCYRGAA_UNKNOWN ,  SP3_Q3 ,  ATTCTTT_MIR186 ,  GCAAAAA_MIR129 ,  GGGCGGR_SP1_Q6 ,  STAT5A_03 ,  CREBP1_01 ,  AAGWWRNYGGC_UNKNOWN ,  HMX1_01 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  CTTTAAR_UNKNOWN ,  NF1_Q6_01 ,  TGTTTGY_HNF3_Q6 ,  GACTGTT_MIR212_MIR132 ,  OCT1_06 ,  HMEF2_Q6 ,  RNGTGGGC_UNKNOWN ,  GGCAGCT_MIR22 ,  AP2_Q6 ,  MTF1_Q4 ,  HAND1E47_01 ,  GATGKMRGCG_UNKNOWN ,  TTGTTT_FOXO4_01 ,  SCGGAAGY_ELK1_02 ,  YY1_02 ,  ACAWNRNSRCGG_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  NFKB_Q6_01 ,  TAANNYSGCG_UNKNOWN ,  NFKB_Q6 ,  TATTATA_MIR374 ,  GGGTGGRR_PAX4_03

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-342 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-363 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-500 ,  Predicted Gene Targets for miR-543

View More

View Less

Cytogenetic Map:

22q13.2

search → result