QuickView for EPHB1;jsessionid=7E2F25492B15854B87B944A29E40C6AA (gene)

Gene Symbol:

EPHB1 Homo sapiens

Full name:

EPH receptor B1

Synonyms:

ELK, EPHT2, Hek6, NET, ephrin type-B receptor 1, EK6, EPH-like kinase 6, eph tyrosine kinase 2, neuronally-expressed EPH-related tyrosine kinase, soluble EPHB1 variant 1, tyrosine-protein kinase receptor EPH-2

Genomic Location:

Chr 3: 135996950-136461999

Description:

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which ar...

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Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MCAATNNNNNGCG_UNKNOWN ,  GATA1_01 ,  E2F1_Q4_01 ,  FOXO4_01 ,  SRF_Q6 ,  E2F4DP1_01 ,  AAAYWAACM_HFH4_01 ,  FOXD3_01 ,  CCTGAGT_MIR510 ,  E2F_Q6_01 ,  WGTTNNNNNAAA_UNKNOWN ,  ZIC3_01 ,  EGR2_01 ,  TGCAAAC_MIR452 ,  E2F_Q6 ,  MEF2_01 ,  AGCTCCT_MIR28 ,  AP2_Q6_01 ,  SP3_Q3 ,  E2F_Q4 ,  YGCANTGCR_UNKNOWN ,  ATTCTTT_MIR186 ,  GCAAAAA_MIR129 ,  HNF3B_01 ,  E2F1DP2_01 ,  AHR_Q5 ,  FOXO1_01 ,  TCCAGAT_MIR5165P ,  SPZ1_01 ,  AP2_Q3 ,  SOX5_01 ,  E2F_03 ,  E2F1DP1_01 ,  E2F_Q4_01 ,  RNGTGGGC_UNKNOWN ,  TTGCCAA_MIR182 ,  AP2_Q6 ,  E2F1DP1RB_01 ,  E2F_02 ,  SMAD4_Q6 ,  E2F1_Q3 ,  E2F4DP2_01 ,  EGR1_01 ,  P300_01 ,  AAACCAC_MIR140 ,  AACTTT_UNKNOWN ,  E2F_Q3 ,  PPARA_02 ,  PAX2_02 ,  E2F_Q3_01 ,  CCAWWNAAGG_SRF_Q4 ,  EGR3_01 ,  GGGTGGRR_PAX4_03 ,  E2F1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-28 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-452

Cytogenetic Map:

3q22.2

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