QuickView for EREG (gene)

Gene Symbol:

EREG Homo sapiens

Full name:

epiregulin

Synonyms:

EPR, ER, Ep, proepiregulin

Genomic Location:

Chr 4: 75449724-75473341

Description:

This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including ...

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This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  TTANTCA_UNKNOWN ,  AML_Q6 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  TATAAA_TATA_01 ,  CDX2_Q5 ,  CAGCTTT_MIR320 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  NKX25_02 ,  IRF_Q6 ,  TAATTA_CHX10_01 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  ICSBP_Q6 ,  ISRE_01 ,  TCF1P_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-330

Cytogenetic Map:

4q13.3

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