QuickView for ESX1 (gene)

Gene Symbol:

ESX1 Homo sapiens

Full name:

ESX homeobox 1

Synonyms:

ESX1L, ESXR1, homeobox protein ESX1, ESX1-related protein, extraembryonic, spermatogenesis, homeobox 1 homolog

Genomic Location:

Chr X: 103381375-103386244

Description:

This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to...

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This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis.

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Orthologs:

Mus musculus ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Cytogenetic Map:

Xq22.2

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