QuickView for EWS-ATF1 (gene)
- Gene Symbol:
- ATF1
Homo sapiens - Full name:
- activating transcription factor 1
- Synonyms:
- EWS-ATF1, FUS/ATF-1, TREB36, cyclic AMP-dependent transcription factor ATF-1, cAMP-dependent transcription factor ATF-1
- Genomic Location:
- Chr 12: 49444086-49501174
- Description:
-
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 6...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
12q13.12
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nucleic acid binding | protein-containing complex binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | identical protein binding | protein heterodimerization activity | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | regulation of neurogenesis | regulation of cell development | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | response to metal ion | cell differentiation | nervous system development | neurogenesis | regulation of DNA replication | generation of neurons | positive regulation of cellular biosynthetic process | cellular process | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | response to inorganic substance | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | cellular biosynthetic process | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | positive regulation of neuron projection development | multicellular organism development | positive regulation of DNA replication | regulation of neuron differentiation | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | positive regulation of cell projection organization | regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | biosynthetic process | aromatic compound biosynthetic process | cellular protein-containing complex assembly | regulation of cellular metabolic process | regulation of RNA metabolic process | protein-containing complex assembly | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | response to organic substance | anatomical structure development | positive regulation of neurogenesis | metabolic process | positive regulation of cell development | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | transcription, DNA-templated | regulation of transcription, DNA-templated | response to organic cyclic compound | cellular macromolecule biosynthetic process | regulation of nervous system development | regulation of developmental process | positive regulation of DNA metabolic process | developmental process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | response to cobalt ion | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | positive regulation of neuron differentiation | regulation of cell projection organization | cellular metabolic process | regulation of cellular component organization | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
nuclear transcription factor complex | intracellular membrane-bounded organelle | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | intracellular organelle | protein-containing complex | nucleoplasm | ATF1-ATF4 transcription factor complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
