QuickView for EYA4 (gene)

Gene Symbol:

EYA4 Homo sapiens

Full name:

EYA transcriptional coactivator and phosphatase 4

Synonyms:

CMD1J, DFNA10, eyes absent homolog 4, dJ78N10.1 (eyes absent), eyes absent-like protein 4

Genomic Location:

Chr 6: 133604188-133894358

Description:

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autoso...

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This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTCTATG_MIR368 ,  ZIC1_01 ,  CACGTG_MYC_Q2 ,  SMAD3_Q6 ,  TGTGTGA_MIR377 ,  GTGACTT_MIR224 ,  ACTTTAT_MIR1425P ,  FAC1_01 ,  E2A_Q2 ,  GATA1_04 ,  ACTGTGA_MIR27A_MIR27B ,  CDPCR3HD_01 ,  TCCCRNNRTGC_UNKNOWN ,  ACATTCC_MIR1_MIR206 ,  CAGGTG_E12_Q6 ,  CAGCTTT_MIR320 ,  EGR_Q6 ,  TGCCTTA_MIR124A ,  GGGCGGR_SP1_Q6 ,  AAAGACA_MIR511 ,  GTGCCTT_MIR506 ,  EN1_01 ,  AACATTC_MIR4093P ,  AP2REP_01 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  ISRE_01 ,  AACTTT_UNKNOWN ,  CRX_Q4 ,  ACCTGTTG_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-324-5p ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-431 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-499 ,  Predicted Gene Targets for miR-543

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miRNA binding sites
(Source: miRecords):

hsa-miR-124 Targeted Genes

Cytogenetic Map:

6q23.2

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