QuickView for Elongin C (gene)

Gene Symbol:

ELOC Homo sapiens

Full name:

elongin C

Synonyms:

SIII, TCEB1, elongin-C, transcription elongation factor B polypeptide 1, RNA polymerase II transcription factor SIII subunit C, SIII p15, elongin 15 kDa subunit, transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C), transcription elongation factor B subunit 1

Genomic Location:

Chr 8: 75021188-75046900

Description:

This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally activ...

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This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MAZR_01 ,  GGGAGGRR_MAZ_Q6 ,  TCCCRNNRTGC_UNKNOWN ,  CAGGTA_AREB6_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  MZF1_02 ,  GGGTGGRR_PAX4_03

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-374

Cytogenetic Map:

8q21.11

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