QuickView for EphA4 (gene)

Gene Symbol:

EPHA4 Homo sapiens

Full name:

EPH receptor A4

Synonyms:

HEK8, SEK, TYRO1, ephrin type-A receptor 4, EK8, EPH-like kinase 8, TYRO1 protein tyrosine kinase, receptor protein-tyrosine kinase HEK8, tyrosine-protein kinase TYRO1, tyrosine-protein kinase receptor SEK

Genomic Location:

Chr 2: 221990991-222145254

Description:

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibron...

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This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTGTAT_MIR381 ,  ATAAGCT_MIR21 ,  GTGCCAT_MIR183 ,  GCATTTG_MIR105 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  GCAAGGA_MIR502 ,  CTATGCA_MIR153 ,  AAGCAAT_MIR137 ,  CACCAGC_MIR138 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GACAATC_MIR219 ,  AAGGGAT_MIR188 ,  AAAGACA_MIR511 ,  GACAGGG_MIR339 ,  ATATGCA_MIR448 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  ACAGGGT_MIR10A_MIR10B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-136 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-188 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

2q36.1

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