Correlation Engine 2.0
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QuickView for Eps15 (gene)

Gene Symbol:
EPS15 Homo sapiens Homo sapiens
Full name:
epidermal growth factor receptor pathway substrate 15
AF-1P, AF1P, MLLT5, epidermal growth factor receptor substrate 15, ALL1 fused gene from chromosome 1, protein AF-1p
Genomic Location:
Chr 1: 51592523-51757583
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Mus musculus Rattus norvegicus Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 1

GO Molecular Function

cadherin binding | cation binding | SH3 domain binding | polyubiquitin modification-dependent protein binding | protein domain specific binding | modification-dependent protein binding | identical protein binding | ion binding | cell adhesion molecule binding | protein binding | calcium ion binding | metal ion binding

GO Biological Process

receptor-mediated endocytosis of virus by host cell | establishment of localization | negative regulation of cellular process | positive regulation of receptor recycling | membrane organization | intracellular transport | cellular process | localization | protein transport | negative regulation of signaling | macromolecule localization | establishment of localization in cell | cytosolic transport | interspecies interaction between organisms | regulation of cellular process | regulation of metabolic process | epidermal growth factor receptor signaling pathway | negative regulation of epidermal growth factor receptor signaling pathway | cellular component organization | entry into host cell | viral life cycle | Golgi to endosome transport | response to stimulus | endosomal transport | regulation of cell proliferation | cellular localization | ERBB signaling pathway | cellular component assembly | regulation of signal transduction | post-Golgi vesicle-mediated transport | viral entry into host cell | organic substance transport | positive regulation of cellular metabolic process | enzyme linked receptor protein signaling pathway | peptide transport | vesicle-mediated transport | cell proliferation | cellular protein-containing complex assembly | cell communication | regulation of cellular metabolic process | endocytic recycling | Golgi vesicle transport | viral process | protein-containing complex assembly | import into cell | cell surface receptor signaling pathway | clathrin coat assembly | amide transport | endocytosis | negative regulation of ERBB signaling pathway | regulation of epidermal growth factor receptor signaling pathway | establishment of protein localization | vesicle organization | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of ERBB signaling pathway | protein localization | receptor-mediated endocytosis | organelle organization | regulation of receptor recycling | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | positive regulation of signaling | signal transduction | regulation of signaling

GO Cellular Component

clathrin coat of endocytic vesicle | basal plasma membrane | intracellular membrane-bounded organelle | early endosome membrane | apical plasma membrane | clathrin-coated endocytic vesicle membrane | ciliary membrane | endocytic vesicle membrane | clathrin-coated vesicle membrane | organelle membrane | cell projection membrane | vesicle coat | clathrin-coated vesicle | clathrin coat of coated pit | cytoplasmic vesicle | basal part of cell | cell | plasma membrane protein complex | AP-2 adaptor complex | cytoplasm | clathrin-coated endocytic vesicle | intracellular organelle | apical part of cell | AP-type membrane coat adaptor complex | inclusion body | endosome membrane | protein-containing complex | cell projection | clathrin adaptor complex | endomembrane system | plasma membrane | cilium | vesicle | clathrin-coated pit | endosome | coated vesicle membrane | membrane-bounded organelle | clathrin coat | aggresome | organelle | vesicle membrane | cell periphery | clathrin vesicle coat | early endosome | basolateral plasma membrane | cytosol | intracellular vesicle | endocytic vesicle | intracellular | membrane | cytoplasmic vesicle membrane | membrane coat | coated vesicle