QuickView for Eps8 (gene)

Gene Symbol:

EPS8 Homo sapiens

Full name:

epidermal growth factor receptor pathway substrate 8

Synonyms:

DFNB102, epidermal growth factor receptor kinase substrate 8

Genomic Location:

Chr 12: 15664342-15833601

Description:

This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate ...

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This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FAC1_01 ,  IRF1_Q6 ,  MYCMAX_B ,  CAGGTG_E12_Q6 ,  AGTCAGC_MIR345 ,  GTGCCTT_MIR506 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  CTTTGT_LEF1_Q2

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

12p12.3

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