QuickView for FEN1 (gene)

Gene Symbol:

FEN1 Homo sapiens

Full name:

flap structure-specific endonuclease 1

Synonyms:

FEN-1, MF1, RAD2, flap endonuclease 1, DNase IV, maturation factor-1

Genomic Location:

Chr 11: 61316726-61321286

Description:

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the su...

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The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  TCANNTGAY_SREBP1_01 ,  CACGTG_MYC_Q2 ,  CATTGTYY_SOX9_B1 ,  MAX_01 ,  PEA3_Q6 ,  GGAMTNNNNNTCCY_UNKNOWN ,  ARNT_02 ,  GR_Q6_01 ,  SOX9_B1 ,  SREBP1_01 ,  RRAGTTGT_UNKNOWN ,  FOXJ2_01 ,  ACTAYRNNNCCCR_UNKNOWN ,  USF_01 ,  GR_01 ,  USF2_Q6 ,  USF_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-378

Cytogenetic Map:

11q12.2

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