QuickView for FER (gene)
- Gene Symbol:
- FER
Homo sapiens - Full name:
- FER tyrosine kinase
- Synonyms:
- PPP1R74, TYK3, p94-Fer, tyrosine-protein kinase Fer, feline encephalitis virus-related kinase FER, fer (fps/fes related) tyrosine kinase, fujinami poultry sarcoma/Feline sarcoma-related protein Fer, phosphoprotein NCP94, protein phosphatase 1, regulatory subunit 74, proto-oncogene c-Fer, tyrosine kinase 3
- Genomic Location:
- Chr 5: 108111422-108551272
- Description:
-
The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chr...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Canis lupus familiaris , Gallus gallus , Pan troglodytes , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
5q21.3
GO Molecular Function
protein phosphatase 1 binding | enzyme binding | ribonucleotide binding | lipid binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | protein phosphatase binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | epidermal growth factor receptor binding | non-membrane spanning protein tyrosine kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | growth factor receptor binding | drug binding | kinase activity | phosphatase binding | heterocyclic compound binding | small molecule binding
GO Biological Process
negative regulation of leukocyte activation | regulation of supramolecular fiber organization | cell morphogenesis | positive regulation of locomotion | negative regulation of immune system process | diapedesis | actin filament-based process | response to cytokine | positive regulation of cellular component organization | cell motility | immune response-regulating signaling pathway | response to lipopolysaccharide | regulation of cellular localization | interleukin-6-mediated signaling pathway | intracellular signal transduction | regulation of localization | cell-substrate adhesion | positive regulation of DNA-binding transcription factor activity | peptidyl-amino acid modification | actin cytoskeleton organization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | response to hormone | insulin receptor signaling pathway via phosphatidylinositol 3-kinase | negative regulation of cellular process | cellular response to stem cell factor stimulus | cell-cell adhesion mediated by cadherin | substrate adhesion-dependent cell spreading | microtubule cytoskeleton organization | cell differentiation | JAK-STAT cascade | peptidyl-tyrosine phosphorylation | regulation of organelle organization | positive regulation of cellular component movement | regulation of actin polymerization or depolymerization | regulation of fibroblast migration | microtubule-based process | extracellular matrix-cell signaling | cellular process | positive regulation of actin filament polymerization | regulation of cell motility | localization | positive regulation of immune effector process | response to growth factor | response to peptide hormone | negative regulation of mast cell activation | regulation of immune response | regulation of cellular process | regulation of metabolic process | regulation of protein complex assembly | cellular response to organonitrogen compound | cellular component organization | regulation of mast cell degranulation | regulation of actin filament length | response to stimulus | positive regulation of immune system process | response to stress | regulation of cell proliferation | response to peptide | response to molecule of bacterial origin | regulation of cellular component size | protein modification process | macromolecule modification | regulation of intracellular transport | leukocyte migration | regulation of nucleic acid-templated transcription | locomotion | response to nitrogen compound | cellular response to interleukin-6 | cellular response to hormone stimulus | regulation of cell projection assembly | response to external biotic stimulus | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | regulation of actin cytoskeleton organization | cell migration | cellular response to peptide hormone stimulus | phosphorus metabolic process | regulation of actin filament organization | cellular response to insulin stimulus | cellular response to oxidative stress | regulation of phosphorylation | regulation of gene expression | platelet-derived growth factor receptor signaling pathway | cellular response to stress | response to lipid | cellular response to peptide | cell cycle | insulin receptor signaling pathway | regulation of mast cell activation | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | cytokine-mediated signaling pathway | positive regulation of protein complex assembly | regulation of cellular component movement | response to oxidative stress | Fc-epsilon receptor signaling pathway | response to platelet-derived growth factor | positive regulation of cell migration | cellular response to cytokine stimulus | cell proliferation | regulation of cellular protein metabolic process | negative regulation of immune response | phosphorylation | Kit signaling pathway | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | response to bacterium | cell communication | regulation of cellular metabolic process | regulation of actin filament polymerization | negative regulation of cell activation | positive regulation of cytoskeleton organization | regulation of protein metabolic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | negative regulation of mast cell activation involved in immune response | protein tyrosine kinase activity | positive regulation of molecular function | protein metabolic process | response to organic substance | regulation of DNA-binding transcription factor activity | regulation of exocytosis | response to insulin | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | metabolic process | positive regulation of supramolecular fiber organization | regulation of RNA biosynthetic process | actin cytoskeleton reorganization | regulation of vesicle-mediated transport | regulation of secretion | cell adhesion | protein kinase activity | cellular response to reactive oxygen species | positive regulation of cellular component biogenesis | organic substance metabolic process | regulation of epidermal growth factor receptor signaling pathway | response to reactive oxygen species | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | regulation of phosphate metabolic process | cytoskeleton organization | cell-cell adhesion | regulation of regulated secretory pathway | non-membrane spanning protein tyrosine kinase activity | regulation of cell communication | signaling | regulation of transcription, DNA-templated | cell development | regulation of ERBB signaling pathway | cellular protein metabolic process | anatomical structure morphogenesis | response to biotic stimulus | tyrosine phosphorylation of STAT protein | kinase activity | developmental process | organelle organization | Fc receptor signaling pathway | cellular protein modification process | cellular extravasation | regulation of transport | positive regulation of protein polymerization | regulation of lamellipodium assembly | response to organonitrogen compound | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of actin filament-based process | cellular response to macrophage colony-stimulating factor stimulus | regulation of cell projection organization | immune system process | cellular metabolic process | cellular response to organic substance | positive regulation of cell motility | response to interleukin-6 | chemotaxis | regulation of cellular component organization | regulation of cytoskeleton organization | response to other organism | signal transduction | regulation of signaling | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
cytoplasmic side of plasma membrane | chromosome | intracellular membrane-bounded organelle | extrinsic component of membrane | cell | cytoplasmic side of membrane | nuclear lumen | extrinsic component of plasma membrane | lamellipodium | cytoplasm | intracellular organelle | actin cytoskeleton | cell projection | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | chromatin | cell leading edge | nuclear chromosome | microtubule cytoskeleton | cytoplasmic region | cell cortex | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | nuclear chromatin | cytosol | cytoskeleton | intracellular | cell junction | membrane
