QuickView for FGE (gene)

Gene Symbol:

SUMF1 Homo sapiens

Full name:

sulfatase modifying factor 1

Synonyms:

AAPA3037, FGE, UNQ3037, sulfatase-modifying factor 1, C-alpha-formylglycine-generating enzyme 1, FGly-generating enzyme

Genomic Location:

Chr 3: 4377830-4483954

Description:

This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multipl...

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This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

USF_Q6 ,  CACGTG_MYC_Q2 ,  MAX_01 ,  TGTGTGA_MIR377 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  CTTTAAR_UNKNOWN ,  USF_01 ,  GTGCCTT_MIR506 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  USF_02 ,  CACTTTG_MIR520G_MIR520H

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-124a

Cytogenetic Map:

3p26.1

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