QuickView for FGFRL1 (gene)

Gene Symbol:

FGFRL1 Homo sapiens

Full name:

fibroblast growth factor receptor like 1

Synonyms:

FGFR5, FHFR, fibroblast growth factor receptor-like 1, FGF homologous factor receptor, FGF receptor-like protein 1, FGFR-5, FGFR-like protein, fibroblast growth factor receptor 5

Genomic Location:

Chr 4: 995610-1010686

Description:

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracel...

View Full Description

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SRF_Q6 ,  GGGAGGRR_MAZ_Q6 ,  GGGYGTGNY_UNKNOWN ,  CAGGTG_E12_Q6 ,  SRF_Q4 ,  TAATAAT_MIR126 ,  RNGTGGGC_UNKNOWN ,  WWTAAGGC_UNKNOWN ,  TATA_01 ,  SRF_Q5_01 ,  CCAWWNAAGG_SRF_Q4 ,  SRF_C

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-495

Cytogenetic Map:

4p16.3

search → result