QuickView for FMO 4 (gene)
- Gene Symbol:
- FMO4
Homo sapiens - Full name:
- flavin containing monooxygenase 4
- Synonyms:
- FMO2, dimethylaniline monooxygenase [N-oxide-forming] 4, FMO 4, dimethylaniline oxidase 4, hepatic flavin-containing monooxygenase 4
- Genomic Location:
- Chr 1: 169550110-169577847
- Description:
-
Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes cluster...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
GATA1_03 , E2F1_Q4_01 , E2F4DP1_01 , E2F_Q6_01 , GATAAGR_GATA_C , E2F1_Q4 , E2F_Q6 , E2F_Q4 , E2F1DP2_01 , E2F_03
- Cytogenetic Map:
-
1q24.3
| Transcripts Names |
|---|
| NM_002022 |
| XM_005245046 |
| XR_002959842 |
| XM_005245048 |
| XM_011509347 |
| XM_011509348 |
| XM_006711243 |
| XM_005245045 |
GO Molecular Function
NADP binding | cofactor binding | nucleotide binding | flavin adenine dinucleotide binding | coenzyme binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | anion binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | ion binding | organic cyclic compound binding | heterocyclic compound binding | oxidoreductase activity | N,N-dimethylaniline monooxygenase activity | small molecule binding
GO Biological Process
cellular process | catabolic process | drug catabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | drug metabolic process | metabolic process | oxidation-reduction process | cellular metabolic process | oxidoreductase activity | N,N-dimethylaniline monooxygenase activity
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | organelle | intracellular | membrane
