QuickView for FMOD;jsessionid=59C2B3ADA14CAD719BAD7667A9FD0CC1 (gene)

Gene Symbol:

FMOD Homo sapiens

Full name:

fibromodulin

Synonyms:

FM, SLRR2E, fibromodulin, KSPG fibromodulin, collagen-binding 59 kDa protein, keratan sulfate proteoglycan fibromodulin

Genomic Location:

Chr 1: 201576375-201586912

Description:

Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, t...

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Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  MYB_Q5_01 ,  TGCCAAR_NF1_Q6 ,  MYB_Q6 ,  CTTTGT_LEF1_Q2 ,  AAGTCCA_MIR422B_MIR422A

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-378*

Cytogenetic Map:

1q32.1

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