QuickView for FOXA2;jsessionid=BB53768A64D1432CCD5F785C7D4426C5 (gene)
- Gene Symbol:
- FOXA2
Homo sapiens - Full name:
- forkhead box A2
- Synonyms:
- HNF3B, TCF3B, hepatocyte nuclear factor 3-beta, HNF-3-beta, HNF-3B, TCF-3B, forkhead box protein A2, hepatic nuclear factor-3-beta, transcription factor 3B
- Genomic Location:
- Chr 20: 22509823-22514102
- Description:
-
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancr...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
HNF3ALPHA_Q6 , HNF1_01 , MZF1_01 , AAAYWAACM_HFH4_01 , HP1SITEFACTOR_Q6 , AREB6_04 , FAC1_01 , HNF1_C , ZIC3_01 , CTTTGA_LEF1_Q2
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
20p11.21
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | protein domain specific binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | response to extracellular stimulus | negative regulation of phosphorylation | positive regulation of macromolecule biosynthetic process | response to nutrient levels | response to cytokine | regulation of cellular localization | regulation of localization | positive regulation of embryonic development | regulation of carbohydrate metabolic process | negative regulation of cellular process | negative regulation of kinase activity | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | cell differentiation | nervous system development | cellular response to extracellular stimulus | neurogenesis | positive regulation of cell adhesion | regulation of peptide hormone secretion | generation of neurons | negative regulation of hexokinase activity | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | cell fate specification | chromatin organization | regulation of embryonic development | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of transcription from RNA polymerase II promoter by glucose | endocrine pancreas development | cellular component organization | negative regulation of glucokinase activity | regulation of peptide secretion | response to stimulus | negative regulation of epithelial to mesenchymal transition | regulation of insulin secretion | cellular nitrogen compound biosynthetic process | positive regulation of cell-cell adhesion | cellular nitrogen compound metabolic process | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of wound healing | regulation of peptide transport | regulation of cell adhesion | cellular biosynthetic process | embryo development | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | system development | cellular response to nutrient levels | nitrogen compound metabolic process | negative regulation of phosphate metabolic process | carbon catabolite regulation of transcription from RNA polymerase II promoter | multicellular organism development | negative regulation of catalytic activity | regulation of catalytic activity | regulation of insulin secretion involved in cellular response to glucose stimulus | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | regulation of gene expression | pancreas development | positive regulation of cellular metabolic process | adult locomotory behavior | regulation of cell-cell adhesion mediated by cadherin | regulation of blood coagulation | regulation of nitrogen compound metabolic process | negative regulation of DNA-binding transcription factor activity | regulation of transcription by RNA polymerase II | response to nutrient | carbon catabolite regulation of transcription | biosynthetic process | locomotory behavior | positive regulation of transcription from RNA polymerase II promoter by glucose | aromatic compound biosynthetic process | positive regulation of gastrulation | positive regulation of transcription by glucose | endocrine system development | gastrulation with mouth forming second | carbon catabolite activation of transcription from RNA polymerase II promoter | cell communication | regulation of cellular metabolic process | anterior/posterior axis specification | regulation of RNA metabolic process | embryonic morphogenesis | neuron differentiation | negative regulation of carbohydrate metabolic process | cellular response to nutrient | positive regulation of cell-cell adhesion mediated by cadherin | DNA-binding transcription factor activity | regulation of establishment of protein localization | regionalization | axis specification | response to organic substance | regulation of kinase activity | regulation of DNA-binding transcription factor activity | anatomical structure development | regulation of glucose metabolic process | metabolic process | cell fate commitment | regulation of RNA biosynthetic process | primitive streak formation | regulation of body fluid levels | regulation of secretion | behavior | nucleobase-containing compound metabolic process | organic substance metabolic process | animal organ development | gene expression | regulation of protein secretion | negative regulation of detection of glucose | regulation of phosphate metabolic process | transcription, DNA-templated | dopaminergic neuron differentiation | anatomical structure formation involved in morphogenesis | adult behavior | regulation of response to wounding | negative regulation of transcription from RNA polymerase II promoter by glucose | regulation of cell communication | negative regulation of molecular function | regulation of transcription, DNA-templated | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of developmental process | developmental process | organelle organization | regulation of gastrulation | regulation of transport | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | heterocycle metabolic process | regulation of transcription by glucose | positive regulation of metabolic process | chromosome organization | gastrulation | cellular metabolic process | regulation of protein localization | response to interleukin-6 | negative regulation of cell differentiation | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular | cell junction
