QuickView for FOXO4 (gene)
- Gene Symbol:
- FOXO4
Homo sapiens - Full name:
- forkhead box O4
- Synonyms:
- AFX, AFX1, MLLT7, forkhead box protein O4, fork head domain transcription factor AFX1, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
- Genomic Location:
- Chr X: 70232751-70240109
- Description:
-
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
Xq13.1
GO Molecular Function
sequence-specific DNA binding | beta-catenin binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | enzyme binding | nucleic acid binding | chromatin binding | DNA binding | promoter-specific chromatin binding | identical protein binding | organic cyclic compound binding | protein binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | heterocyclic compound binding
GO Biological Process
protein modification by small protein removal | RNA metabolic process | transcription by RNA polymerase II | response to extracellular stimulus | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | response to nutrient levels | proteolysis | regulation of localization | response to immobilization stress | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | glucose homeostasis | positive regulation of cellular component movement | positive regulation of cellular biosynthetic process | cellular process | regulation of cell motility | mitotic DNA integrity checkpoint | negative regulation of nucleic acid-templated transcription | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | response to peptide hormone | regulation of cell differentiation | muscle structure development | regulation of angiogenesis | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | protein deubiquitination | regulation of vasculature development | response to stimulus | regulation of mitotic cell cycle phase transition | response to stress | negative regulation of G2/M transition of mitotic cell cycle | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | mitotic G2 DNA damage checkpoint | negative regulation of angiogenesis | response to peptide | regulation of cell cycle phase transition | regulation of smooth muscle cell migration | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | response to nitrogen compound | cellular response to hormone stimulus | regulation of cell cycle G2/M phase transition | system development | nitrogen compound metabolic process | negative regulation of mitotic cell cycle phase transition | mitotic DNA damage checkpoint | multicellular organism development | negative regulation of cell cycle G2/M phase transition | cellular response to peptide hormone stimulus | positive regulation of smooth muscle cell migration | cellular response to DNA damage stimulus | cellular response to insulin stimulus | positive regulation of cell cycle | regulation of gene expression | cellular response to stress | cellular response to peptide | cell cycle | insulin receptor signaling pathway | regulation of cell cycle arrest | positive regulation of cellular metabolic process | regulation of smooth muscle cell differentiation | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | regulation of cellular component movement | regulation of transcription by RNA polymerase II | negative regulation of G0 to G1 transition | stem cell differentiation | negative regulation of smooth muscle cell differentiation | positive regulation of cell migration | biosynthetic process | aromatic compound biosynthetic process | cell communication | regulation of cellular metabolic process | homeostatic process | regulation of locomotion | regulation of RNA metabolic process | regulation of mitotic cell cycle | positive regulation of cell cycle arrest | mitotic G2/M transition checkpoint | response to water-immersion restraint stress | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | DNA-binding transcription factor activity | response to organic substance | cell cycle arrest | response to insulin | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of mitotic cell cycle | chemical homeostasis | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | protein modification by small protein conjugation or removal | regulation of G0 to G1 transition | transcription, DNA-templated | negative regulation of cell cycle | signaling | regulation of transcription, DNA-templated | cellular protein metabolic process | cellular macromolecule biosynthetic process | regulation of developmental process | developmental process | regulation of muscle cell differentiation | positive regulation of cell cycle process | cellular protein modification process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | negative regulation of muscle cell differentiation | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | cellular response to organic substance | positive regulation of cell motility | DNA damage checkpoint | cell cycle checkpoint | aging | carbohydrate homeostasis | negative regulation of cell differentiation | muscle organ development | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | nucleoplasm | nuclear speck | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
