QuickView for FPGS;jsessionid=6EADC2567EEF483DD36D21A40985240D (gene)

Gene Symbol:

FPGS Homo sapiens

Full name:

folylpolyglutamate synthase

Synonyms:

folylpolyglutamate synthase, mitochondrial, folylpoly-gamma-glutamate synthetase, tetrahydrofolate synthase, tetrahydrofolylpolyglutamate synthase

Genomic Location:

Chr 9: 129604975-129616377

Description:

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moiet...

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This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RYTTCCTG_ETS2_B ,  CACGTG_MYC_Q2 ,  RNGTGGGC_UNKNOWN ,  IK2_01

Cytogenetic Map:

9q34.11

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