QuickView for FRS3;jsessionid=32F60958802AF92797D0D598E563EAF6 (gene)
- Gene Symbol:
- FRS3
Homo sapiens - Full name:
- fibroblast growth factor receptor substrate 3
- Synonyms:
- FRS2-beta, FRS2B, FRS2beta, SNT-2, SNT2, fibroblast growth factor receptor substrate 3, FGFR substrate 3, FGFR-signaling adaptor SNT2, suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor), testicular tissue protein Li 71
- Genomic Location:
- Chr 6: 41845892-41855608
- Description:
-
This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
6p21.1
GO Molecular Function
guanyl-nucleotide exchange factor activity | GTPase binding | enzyme binding | signaling receptor binding | Ras GTPase binding | molecular function regulator | identical protein binding | fibroblast growth factor receptor binding | protein binding | Ras guanyl-nucleotide exchange factor activity | small GTPase binding | growth factor receptor binding
GO Biological Process
guanyl-nucleotide exchange factor activity | intracellular signal transduction | cellular process | response to growth factor | regulation of cellular process | MAPK cascade | response to stimulus | cellular response to fibroblast growth factor stimulus | signal transduction by protein phosphorylation | protein modification process | macromolecule modification | molecular function regulator | nitrogen compound metabolic process | phosphorus metabolic process | fibroblast growth factor receptor signaling pathway | enzyme linked receptor protein signaling pathway | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | protein metabolic process | response to organic substance | cell surface receptor signaling pathway | metabolic process | Ras guanyl-nucleotide exchange factor activity | organic substance metabolic process | signaling | cellular protein metabolic process | cellular protein modification process | response to fibroblast growth factor | transmembrane receptor protein tyrosine kinase signaling pathway | cellular metabolic process | cellular response to organic substance | signal transduction | cellular response to growth factor stimulus | macromolecule metabolic process
GO Cellular Component
cell | plasma membrane | cell periphery | intracellular | membrane
