QuickView for Fe65L2 (gene)

Gene Symbol:

APBB3 Homo sapiens

Full name:

amyloid beta precursor protein binding family B member 3

Synonyms:

FE65L2, SRA, amyloid-beta A4 precursor protein-binding family B member 3, FE65-like protein 2, amyloid beta (A4) precursor protein-binding, family B, member 3, amyloid precursor interacting protein, protein Fe65-like 2

Genomic Location:

Chr 5: 139918037-139924373

Description:

The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple trans...

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The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFMUE1_Q6 ,  CCCACAT_MIR2993P ,  ACTTTAT_MIR1425P ,  ATGGYGGA_UNKNOWN ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  CAGTCAC_MIR134 ,  SREBP_Q3 ,  RCGCANGCGY_NRF1_Q6 ,  CAGCTG_AP4_Q5 ,  GGCAGTG_MIR3243P

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-299-3p

Cytogenetic Map:

5q31.3

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