QuickView for Fnip2 (gene)

Gene Symbol:

FNIP2 Homo sapiens

Full name:

folliculin interacting protein 2

Synonyms:

FNIPL, MAPO1, folliculin-interacting protein 2, FNIP1-like protein, O6-methylguanine-induced apoptosis 1 protein

Genomic Location:

Chr 4: 159909632-160047408

Description:

This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis sig...

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This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Cytogenetic Map:

4q32.1

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