QuickView for GAB2 (gene)

Gene Symbol:

GAB2 Homo sapiens

Full name:

GRB2 associated binding protein 2

Synonyms:

GRB2-associated-binding protein 2, Grb2-associated binder 2, growth factor receptor bound protein 2-associated protein 2, pp100

Genomic Location:

Chr 11: 77603990-77806414

Description:

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen rece...

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This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGIF_01 ,  TGANTCA_AP1_C ,  OCT1_B ,  ETS_Q4 ,  TCANNTGAY_SREBP1_01 ,  RYTTCCTG_ETS2_B ,  OCT1_04 ,  TGANNYRGCA_TCF11MAFG_01 ,  OCT1_01 ,  OCT_Q6 ,  CAGGTCC_MIR492 ,  GCANCTGNY_MYOD_Q6 ,  PEA3_Q6 ,  SRY_01 ,  AP1_Q6 ,  CTTTGA_LEF1_Q2 ,  E2A_Q2 ,  MAF_Q6 ,  OCT1_Q5_01 ,  OCT_C ,  GTACAGG_MIR486 ,  TCF4_Q5 ,  TGAYRTCA_ATF3_Q6 ,  OCT1_Q6 ,  NFE2_01 ,  AP1_Q6_01 ,  LEF1_Q2 ,  CAGGTG_E12_Q6 ,  TTCYRGAA_UNKNOWN ,  AP1FJ_Q2 ,  YGCANTGCR_UNKNOWN ,  ACCAAAG_MIR9 ,  SRF_Q4 ,  AP1_Q2_01 ,  MGGAAGTG_GABP_B ,  TGCCAAR_NF1_Q6 ,  MEIS1_01 ,  TGTTTGY_HNF3_Q6 ,  AP1_Q4 ,  TTGTTT_FOXO4_01 ,  PIT1_Q6 ,  PAX5_01 ,  CTGCAGY_UNKNOWN ,  AAGCACT_MIR520F ,  AP1_Q2 ,  TGACAGNY_MEIS1_01 ,  GRE_C ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  FOXM1_01 ,  TGACATY_UNKNOWN ,  ACCATTT_MIR522 ,  CTGRYYYNATT_UNKNOWN ,  AAGCACA_MIR218 ,  TCF11MAFG_01 ,  LMO2COM_01 ,  TCF11_01 ,  LBP1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-486

Cytogenetic Map:

11q14.1

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