QuickView for GADD45A (gene)
- Gene Symbol:
- GADD45A
Homo sapiens - Full name:
- growth arrest and DNA damage inducible alpha
- Synonyms:
- DDIT1, GADD45, growth arrest and DNA damage-inducible protein GADD45 alpha, DDIT-1, DNA damage-inducible transcript 1 protein, DNA damage-inducible transcript-1, growth arrest and DNA-damage-inducible 45 alpha
- Genomic Location:
- Chr 1: 67923471-67926607
- Description:
-
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this ge...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Pan troglodytes , Bos taurus , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
1p31.3
GO Molecular Function
sequence-specific DNA binding | kinase binding | transcription regulatory region DNA binding | core promoter binding | enzyme binding | nucleic acid binding | protein N-terminus binding | RNA polymerase II core promoter sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | identical protein binding | protein heterodimerization activity | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | double-stranded DNA binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | core promoter sequence-specific DNA binding | heterocyclic compound binding
GO Biological Process
negative regulation of phosphorylation | response to radiation | regulation of cell cycle process | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell cycle G1/S phase transition | regulation of programmed cell death | negative regulation of cellular process | negative regulation of kinase activity | regulation of MAP kinase activity | microtubule cytoskeleton organization | negative regulation of protein phosphorylation | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | positive regulation of phosphate metabolic process | microtubule-based process | cellular process | mitotic DNA integrity checkpoint | negative regulation of G1/S transition of mitotic cell cycle | positive regulation of reactive oxygen species metabolic process | positive regulation of protein kinase activity | microtubule organizing center organization | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | cellular component organization | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | cellular response to mechanical stimulus | regulation of mitotic cell cycle phase transition | positive regulation of protein metabolic process | response to stress | negative regulation of protein kinase activity | activation of MAPKKK activity | regulation of cell cycle phase transition | programmed cell death | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | activation of protein kinase activity | DNA repair | regulation of cellular response to stress | apoptotic process | regulation of cyclin-dependent protein serine/threonine kinase activity | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | DNA damage response, signal transduction by p53 class mediator | negative regulation of phosphate metabolic process | mitotic DNA damage checkpoint | negative regulation of catalytic activity | regulation of MAPK cascade | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | positive regulation of cell cycle | signal transduction in response to DNA damage | cellular response to stress | cell cycle | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular response to radiation | positive regulation of p38MAPK cascade | regulation of nitrogen compound metabolic process | positive regulation of JNK cascade | positive regulation of intracellular signal transduction | regulation of cellular protein metabolic process | signal transduction involved in cell cycle checkpoint | mitotic G1 DNA damage checkpoint | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of mitotic cell cycle | positive regulation of molecular function | positive regulation of cell cycle arrest | positive regulation of protein modification process | G1 DNA damage checkpoint | centrosome cycle | cell cycle arrest | regulation of kinase activity | DNA metabolic process | response to mechanical stimulus | regulation of intracellular signal transduction | mitotic cell cycle | metabolic process | negative regulation of mitotic cell cycle | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | negative regulation of cellular protein metabolic process | positive regulation of programmed cell death | signal transduction involved in mitotic cell cycle checkpoint | positive regulation of kinase activity | cellular response to ionizing radiation | regulation of phosphate metabolic process | cytoskeleton organization | regulation of JNK cascade | positive regulation of MAPK cascade | negative regulation of cell cycle | negative regulation of protein metabolic process | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | negative regulation of molecular function | signaling | mitotic cell cycle arrest | positive regulation of phosphorylation | positive regulation of MAP kinase activity | signal transduction involved in DNA damage checkpoint | organelle organization | positive regulation of cell cycle process | mitotic G1/S transition checkpoint | regulation of reactive oxygen species metabolic process | heterocycle metabolic process | signal transduction involved in mitotic G1 DNA damage checkpoint | positive regulation of metabolic process | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | regulation of cell death | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | response to ionizing radiation | positive regulation of signaling | signal transduction | regulation of signaling | regulation of p38MAPK cascade | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | nucleoplasm | nuclear speck | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
