QuickView for GAP43 (gene)

Gene Symbol:

GAP43 Homo sapiens

Full name:

growth associated protein 43

Synonyms:

B-50, PP46, neuromodulin, axonal membrane protein GAP-43, calmodulin-binding protein P-57, nerve growth-related peptide GAP43, neural phosphoprotein B-50, neuron growth-associated protein 43, protein F1

Genomic Location:

Chr 3: 116825142-116922842

Description:

The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding...

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The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  SP1_01 ,  TTANTCA_UNKNOWN ,  TTCCGTT_MIR191 ,  TAAYNRNNTCC_UNKNOWN ,  TTGCACT_MIR130A_MIR301_MIR130B ,  SREBP1_Q6 ,  OCT_C ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  GGGAGGRR_MAZ_Q6 ,  AR_Q6 ,  LEF1_Q6 ,  GGGYGTGNY_UNKNOWN ,  CAGGTA_AREB6_01 ,  YYCATTCAWW_UNKNOWN ,  CAGGTG_E12_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  PXR_Q2 ,  FOXJ2_01 ,  S8_01 ,  GCM_Q2 ,  POU1F1_Q6 ,  TCTCTCC_MIR185 ,  NCX_01 ,  EN1_01 ,  OCT1_02 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  SREBP_Q3 ,  CAGCTG_AP4_Q5 ,  ZF5_B ,  CRX_Q4 ,  ACCTGTTG_UNKNOWN ,  GGGTGGRR_PAX4_03 ,  TCF11MAFG_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-191 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-378* ,  Predicted Gene Targets for miR-452

Cytogenetic Map:

3q13.31

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