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QuickView for GBP1;jsessionid=BB53768A64D1432CCD5F785C7D4426C5 (gene)


Gene Symbol:
GBP1 Homo sapiens Homo sapiens
Full name:
guanylate binding protein 1
Synonyms:
guanylate-binding protein 1, GBP-1, GTP-binding protein 1, guanine nucleotide-binding protein 1, guanylate binding protein 1, interferon-inducible, 67kDa, huGBP-1, interferon-induced guanylate-binding protein 1
Genomic Location:
Chr 1: 89290593-89303479
Description:
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Cytogenetic Map:
chr 1
1p22.2


Transcripts Names
NM_002053
XM_024446351
Protein Names
Q5T8M1
D3DT26
P32455



GO Molecular Function

actin binding | cytokine binding | GDP binding | guanyl ribonucleotide binding | ribonucleoside binding | enzyme binding | ribonucleotide binding | nucleotide binding | hydrolase activity | spectrin binding | carbohydrate derivative binding | pyrophosphatase activity | catalytic activity | cytoskeletal protein binding | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | protein dimerization activity | GTP binding | hydrolase activity, acting on acid anhydrides | nucleoside binding | Hsp90 protein binding | purine ribonucleotide binding | heat shock protein binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding

GO Biological Process

regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | protein homooligomerization | response to virus | negative regulation of MAPK cascade | negative regulation of immune system process | response to cytokine | response to interleukin-1 | regulation of cell morphogenesis | regulation of cellular localization | negative regulation of peptide secretion | regulation of cell development | protein localization to vacuole | regulation of localization | defense response to other organism | regulation of immune system process | negative regulation of cellular process | cellular response to tumor necrosis factor | regulation of protein localization to membrane | defense response | negative regulation of protein phosphorylation | negative regulation of protein secretion | cellular process | localization | regulation of calcium-mediated signaling | negative regulation of signaling | negative regulation of protein localization to plasma membrane | negative regulation of T cell receptor signaling pathway | macromolecule localization | negative regulation of secretion | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of T cell receptor signaling pathway | regulation of cell differentiation | regulation of immune response | regulation of cellular process | regulation of metabolic process | interferon-gamma-mediated signaling pathway | negative regulation of cytokine secretion | cellular component organization | negative regulation of cell morphogenesis involved in differentiation | cellular response to interferon-gamma | regulation of peptide secretion | response to stimulus | negative regulation of protein transport | regulation of cellular protein localization | negative regulation of cell adhesion | response to stress | cellular localization | negative regulation of transport | regulation of protein transport | negative regulation of metabolic process | cellular component assembly | regulation of peptide transport | regulation of cell adhesion | negative regulation of ERK1 and ERK2 cascade | response to external biotic stimulus | regulation of signal transduction | negative regulation of secretion by cell | negative regulation of phosphate metabolic process | regulation of MAPK cascade | protein complex oligomerization | regulation of phosphorylation | negative regulation of cellular protein localization | negative regulation of cytokine production | defense response to virus | regulation of nitrogen compound metabolic process | regulation of cell-substrate adhesion | cytokine-mediated signaling pathway | protein localization to organelle | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | negative regulation of cell-substrate adhesion | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | negative regulation of interleukin-2 production | regulation of protein phosphorylation | regulation of cytokine secretion | protein-containing complex assembly | regulation of cell morphogenesis involved in differentiation | regulation of establishment of protein localization | response to organic substance | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cell surface receptor signaling pathway | regulation of protein localization to plasma membrane | cellular protein localization | negative regulation of interleukin-2 secretion | regulation of secretion | immune response | negative regulation of cellular protein metabolic process | regulation of protein secretion | negative regulation of substrate adhesion-dependent cell spreading | regulation of phosphate metabolic process | response to interferon-gamma | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of signal transduction | signaling | protein localization | regulation of cytokine production | cellular macromolecule localization | response to biotic stimulus | regulation of developmental process | cellular response to interleukin-1 | regulation of transport | innate immune response | immune system process | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | regulation of substrate adhesion-dependent cell spreading | negative regulation of cell development | negative regulation of cell differentiation | regulation of cellular component organization | response to other organism | signal transduction | regulation of signaling | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | organelle membrane | cell | cytoplasm | intracellular organelle | actin cytoskeleton | Golgi apparatus | endomembrane system | plasma membrane | vesicle | Golgi membrane | extracellular region | membrane-bounded organelle | organelle | vesicle membrane | cell periphery | cytosol | cytoskeleton | intracellular | membrane