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QuickView for GCH1 (gene)

Gene Symbol:
GCH1 Homo sapiens Homo sapiens
Full name:
GTP cyclohydrolase 1
DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B, GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I, dystonia 14, guanosine 5'-triphosphate cyclohydrolase I
Genomic Location:
Chr 14: 54378473-54439292
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutati...
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Bos taurus Gallus gallus Danio rerio Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 14

GO Molecular Function

kinase binding | translation initiation factor binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines | guanyl ribonucleotide binding | cofactor binding | ribonucleoside binding | cation binding | protein kinase binding | enzyme binding | mitogen-activated protein kinase binding | ribonucleotide binding | nucleotide binding | coenzyme binding | hydrolase activity | GTP-dependent protein binding | carbohydrate derivative binding | pyrophosphatase activity | catalytic activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | cyclohydrolase activity | protein binding | protein homodimerization activity | zinc ion binding | protein dimerization activity | GTP binding | hydrolase activity, acting on acid anhydrides | transition metal ion binding | GTP cyclohydrolase activity | nucleoside binding | calcium ion binding | purine ribonucleotide binding | GTP cyclohydrolase I activity | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding

GO Biological Process

positive regulation of heart contraction | protein homooligomerization | regulation of blood vessel diameter | positive regulation of blood circulation | response to cytokine | regulation of cellular response to oxidative stress | regulation of response to oxidative stress | response to lipopolysaccharide | catechol-containing compound metabolic process | nitric oxide biosynthetic process | pteridine-containing compound biosynthetic process | defense response | reactive oxygen species metabolic process | polyol metabolic process | phenol-containing compound metabolic process | tetrahydrofolate metabolic process | cellular process | 7,8-dihydroneopterin 3'-triphosphate biosynthetic process | regulation of removal of superoxide radicals | positive regulation of nitric-oxide synthase activity | positive regulation of oxidoreductase activity | positive regulation of catalytic activity | folic acid-containing compound biosynthetic process | regulation of cellular process | regulation of metabolic process | regulation of lung blood pressure | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | folic acid-containing compound metabolic process | tetrahydrobiopterin biosynthetic process | tetrahydrofolate biosynthetic process | response to stimulus | dihydrobiopterin metabolic process | response to pain | regulation of blood vessel size | response to stress | cellular nitrogen compound biosynthetic process | alcohol metabolic process | regulation of blood circulation | regulation of heart rate | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | catecholamine biosynthetic process | blood circulation | cofactor metabolic process | cellular component assembly | reactive oxygen species biosynthetic process | cellular biosynthetic process | pteridine-containing compound metabolic process | dopamine metabolic process | negative regulation of blood pressure | regulation of cellular response to stress | regulation of neurotransmitter levels | positive regulation of monooxygenase activity | organic hydroxy compound metabolic process | regulation of superoxide metabolic process | response to external biotic stimulus | nitrogen compound metabolic process | coenzyme biosynthetic process | phosphorus metabolic process | neuromuscular process controlling posture | protein complex oligomerization | regulation of catalytic activity | regulation of nitric-oxide synthase activity | response to lipid | nervous system process | regulation of blood pressure | organophosphate metabolic process | cofactor biosynthetic process | small molecule metabolic process | cellular amide metabolic process | dopamine biosynthetic process | tetrahydrobiopterin metabolic process | neurotransmitter metabolic process | biosynthetic process | diol biosynthetic process | aromatic compound biosynthetic process | regulation of heart contraction | phosphate-containing compound metabolic process | response to bacterium | regulation of cellular metabolic process | regulation of tube size | drug metabolic process | carboxylic acid metabolic process | positive regulation of molecular function | positive regulation of heart rate | reactive nitrogen species metabolic process | protein-containing complex assembly | multicellular organismal response to stress | response to organic substance | catecholamine metabolic process | regulation of response to reactive oxygen species | vasodilation | metabolic process | regulation of tube diameter | immune response | organic substance metabolic process | amide biosynthetic process | response to interferon-gamma | neurotransmitter biosynthetic process | regulation of oxidoreductase activity | neuromuscular process | organic acid metabolic process | protein heterooligomerization | response to biotic stimulus | nitric oxide metabolic process | regulation of reactive oxygen species metabolic process | innate immune response | cellular modified amino acid metabolic process | heterocycle metabolic process | positive regulation of metabolic process | immune system process | cellular metabolic process | response to tumor necrosis factor | positive regulation of blood vessel diameter | response to other organism | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | neuron projection | organelle membrane | nuclear membrane | cytoplasmic vesicle | cell | nuclear lumen | cytoplasm | intracellular organelle | protein-containing complex | cell projection | endomembrane system | nucleoplasm | nuclear envelope | vesicle | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | neuron projection terminus | cytosol | intracellular vesicle | intracellular | membrane