QuickView for GFER;jsessionid=377DCE537D9D8C5FDE19251AA59471FB (gene)

Gene Symbol:

GFER Homo sapiens

Full name:

growth factor, augmenter of liver regeneration

Synonyms:

ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS, FAD-linked sulfhydryl oxidase ALR, ERV1 homolog, erv1-like growth factor, hepatic regenerative stimulation substance, hepatopoietin protein

Genomic Location:

Chr 16: 1974151-1977751

Description:

The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidn...

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The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ZF5_01 ,  GCCATNTTG_YY1_Q6 ,  GGGNRMNNYCAT_UNKNOWN

Cytogenetic Map:

16p13.3

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