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QuickView for GINS1 (gene)


Gene Symbol:
GINS1 Homo sapiens Homo sapiens
Full name:
GINS complex subunit 1
Synonyms:
PSF1, DNA replication complex GINS protein PSF1, GINS complex subunit 1 (Psf1 homolog), partner of sld five-1
Genomic Location:
Chr 20: 25336323-25377191
Description:
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 20
20p11.21





GO Molecular Function

3'-5' DNA helicase activity | hydrolase activity | pyrophosphatase activity | catalytic activity | nucleoside-triphosphatase activity | DNA helicase activity | hydrolase activity, acting on acid anhydrides | helicase activity | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

GO Biological Process

cellular process | developmental growth | cell cycle DNA replication | 3'-5' DNA helicase activity | inner cell mass cell proliferation | mitotic DNA replication | DNA geometric change | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | DNA-dependent DNA replication | cellular component organization | cellular nitrogen compound metabolic process | cellular biosynthetic process | embryo development | nitrogen compound metabolic process | multicellular organism development | cell cycle | DNA strand elongation involved in mitotic DNA replication | cell proliferation | biosynthetic process | DNA duplex unwinding | DNA strand elongation | chordate embryonic development | embryo development ending in birth or egg hatching | DNA helicase activity | DNA metabolic process | anatomical structure development | mitotic cell cycle | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | blastocyst development | cellular macromolecule biosynthetic process | nuclear DNA replication | developmental process | organelle organization | blastocyst growth | DNA strand elongation involved in DNA replication | DNA conformation change | heterocycle metabolic process | in utero embryonic development | chromosome organization | cellular metabolic process | DNA replication | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | protein-containing complex | protein-DNA complex | nucleoplasm | nuclear chromosome | DNA replication preinitiation complex | membrane-bounded organelle | nucleus | GINS complex | organelle | membrane-enclosed lumen | intracellular