QuickView for GIT2;jsessionid=377DCE537D9D8C5FDE19251AA59471FB (gene)

Gene Symbol:

GIT2 Homo sapiens

Full name:

GIT ArfGAP 2

Synonyms:

CAT-2, CAT2, PKL, ARF GTPase-activating protein GIT2, ARF GAP GIT2, G protein-coupled receptor kinase interacting ArfGAP 2, G protein-coupled receptor kinase-interactor 2, GRK-interacting protein 2, Paxillin kinase linker, cool-associated, tyrosine phosphorylated protein 2, cool-interacting tyrosine-phosphorylated protein 2

Genomic Location:

Chr 12: 108851992-108918483

Description:

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to ...

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This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTATTAT_MIR3693P ,  PU1_Q6 ,  TGANTCA_AP1_C ,  TCANNTGAY_SREBP1_01 ,  GCCATNTTG_YY1_Q6 ,  AP1_Q6_01 ,  YY1_Q6 ,  CAGGTG_E12_Q6 ,  ETS2_B ,  TGCCTTA_MIR124A ,  AHR_Q5 ,  MGGAAGTG_GABP_B ,  E47_01 ,  TTGCCAA_MIR182 ,  ELK1_01 ,  SCGGAAGY_ELK1_02 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  RGAGGAARY_PU1_Q6 ,  CTGCAGY_UNKNOWN ,  CCCNNNNNNAAGWT_UNKNOWN ,  RCGCANGCGY_NRF1_Q6 ,  ETS1_B ,  SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-182

Cytogenetic Map:

12q24.11

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