QuickView for GLP-1 receptor (gene)

Gene Symbol:

GLP1R Homo sapiens

Full name:

glucagon like peptide 1 receptor

Synonyms:

GLP-1, GLP-1-R, GLP-1R, glucagon-like peptide 1 receptor, GLP-1 receptor, GLP1 receptor, seven transmembrane helix receptor

Genomic Location:

Chr 6: 39124595-39163498

Description:

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to...

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This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTGTTGA_MIR505 ,  AGGGCAG_MIR18A ,  GGCAGTG_MIR3243P

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-505

Cytogenetic Map:

6p21.2

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