QuickView for GNRHR2 (gene)

Gene Symbol:

GNRHR2 Homo sapiens

Full name:

gonadotropin releasing hormone receptor 2 (pseudogene)

Synonyms:

GnRH-II-R, GnRH receptor II 5TM, Type II GnRH receptor, gonadotropin-releasing hormone (type 2) receptor 2, pseudogene

Genomic Location:

Chr 1: 144221177-144227433

Description:

In non-hominoid primates and non-mammalian vertebrates, the gonadotropin releasing hormone 2 receptor gene (GnRHR2) encodes a seven-transmembrane G-protein coupled receptor. However, in human, the corresponding reading frame contains a premature stop codon, which has been suggested to encode a selenocysteine residue, but there is no solid evidence ...

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In non-hominoid primates and non-mammalian vertebrates, the gonadotropin releasing hormone 2 receptor gene (GnRHR2) encodes a seven-transmembrane G-protein coupled receptor. However, in human, the corresponding reading frame contains a premature stop codon, which has been suggested to encode a selenocysteine residue, but there is no solid evidence for selenocysteine incorporation (PMID: 12538601). It appears that the human GnRHR2 transcription occurs but the gene does not likely produce a functional multi-transmembrane protein. A non-transcribed pseudogene of GnRHR2 is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene.

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External Links:

Entrez Gene

Transcription Factor
Binding Sites:

LXR_DR4_Q3 ,  NFE2_01 ,  NERF_Q2 ,  CTTTAAR_UNKNOWN ,  HSF2_01 ,  ZF5_B ,  DR4_Q2

Cytogenetic Map:

1q21.1

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