QuickView for GPC4;jsessionid=B2747B5C11B8F6A2B9782A7834861FE4 (gene)

Gene Symbol:

GPC4 Homo sapiens

Full name:

glypican 4

Synonyms:

K-glypican, glypican-4, dJ900E8.1 (glypican 4), glypican proteoglycan 4

Genomic Location:

Chr X: 132262730-132376871

Description:

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These prot...

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Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CMYB_01 ,  TGIF_01 ,  TFIIA_Q6 ,  CEBPA_01 ,  OCT1_B ,  RYTTCCTG_ETS2_B ,  TGGNNNNNNKCCAR_UNKNOWN ,  RSRFC4_01 ,  OCT1_01 ,  YATGNWAAT_OCT_C ,  OCT_Q6 ,  GTGACTT_MIR224 ,  RSRFC4_Q2 ,  CEBP_Q2_01 ,  ATGTACA_MIR493 ,  STAT6_01 ,  AMEF2_Q6 ,  TAAYNRNNTCC_UNKNOWN ,  CTTTGA_LEF1_Q2 ,  PBX1_01 ,  CTAWWWATA_RSRFC4_Q2 ,  MAF_Q6 ,  EGR2_01 ,  TCF4_Q5 ,  GGGAGGRR_MAZ_Q6 ,  MEF2_02 ,  CEBPDELTA_Q6 ,  LEF1_Q6 ,  GGGYGTGNY_UNKNOWN ,  CAGGTA_AREB6_01 ,  MEF2_01 ,  CTCAGGG_MIR125B_MIR125A ,  TTCYRGAA_UNKNOWN ,  AP4_01 ,  CAGGGTC_MIR504 ,  TGCCTTA_MIR124A ,  GGGCGGR_SP1_Q6 ,  ATGTTAA_MIR302C ,  STAT5A_03 ,  MGGAAGTG_GABP_B ,  NKX25_02 ,  RAAGNYNNCTTY_UNKNOWN ,  SOX5_01 ,  PAX8_B ,  OCT1_06 ,  HMEF2_Q6 ,  YCATTAA_UNKNOWN ,  STAT_01 ,  RNGTGGGC_UNKNOWN ,  AATGTGA_MIR23A_MIR23B ,  EN1_01 ,  AP2_Q6 ,  CEBP_Q3 ,  MTF1_Q4 ,  POU3F2_02 ,  AFP1_Q6 ,  IK2_01 ,  MEF2_03 ,  TEF_Q6 ,  CTGAGCC_MIR24 ,  CTTTGT_LEF1_Q2 ,  AACTTT_UNKNOWN ,  ACAWYAAAG_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  ER_Q6 ,  GGGTGGRR_PAX4_03 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-504

Cytogenetic Map:

Xq26.2

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