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QuickView for GRK2;jsessionid=790A193C2C99D413D08938D4AF76E95D (gene)


Gene Symbol:
GRK2 Homo sapiens Homo sapiens
Full name:
G protein-coupled receptor kinase 2
Synonyms:
ADRBK1, BARK1, BETA-ARK1, beta-adrenergic receptor kinase 1, adrenergic beta receptor kinase 1, beta-ARK-1
Genomic Location:
Chr 11: 66790481-66810605
Description:
This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 11
11q13.2





GO Molecular Function

ribonucleotide binding | nucleotide binding | Edg-2 lysophosphatidic acid receptor binding | signaling receptor binding | carbohydrate derivative binding | protein serine/threonine kinase activity | adrenergic receptor binding | catalytic activity | ATP binding | G-protein coupled receptor kinase activity | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | alpha-2A adrenergic receptor binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | beta-adrenergic receptor kinase activity | transferase activity, transferring phosphorus-containing groups | G-protein coupled receptor binding | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding

GO Biological Process

negative regulation of G-protein coupled receptor protein signaling pathway | regulation of muscle system process | heart process | negative regulation of muscle contraction | regulation of localization | regulation of the force of heart contraction by chemical signal | peptidyl-amino acid modification | establishment of localization | response to hormone | negative regulation of cellular process | response to drug | cellular process | regulation of catecholamine secretion | localization | acetylcholine receptor signaling pathway | negative regulation of signaling | interspecies interaction between organisms | regulation of cellular process | heart contraction | entry into host cell | viral life cycle | muscle contraction | response to stimulus | peptidyl-threonine phosphorylation | regulation of blood circulation | protein serine/threonine kinase activity | blood circulation | G-protein coupled receptor signaling pathway | protein modification process | macromolecule modification | response to nitrogen compound | cellular response to hormone stimulus | system development | G-protein coupled receptor kinase activity | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | phosphorus metabolic process | G-protein coupled acetylcholine receptor signaling pathway | tachykinin receptor signaling pathway | positive regulation of catecholamine secretion | regulation of muscle contraction | cellular response to ammonium ion | viral entry into host cell | positive regulation of secretion | viral genome replication | response to ammonium ion | response to acetylcholine | vesicle-mediated transport | regulation of the force of heart contraction | phosphorylation | regulation of heart contraction | protein phosphorylation | phosphate-containing compound metabolic process | cellular response to drug | regulation of striated muscle contraction | cell communication | receptor internalization | heart development | positive regulation of transport | striated muscle contraction | viral process | negative adaptation of signaling pathway | protein metabolic process | response to organic substance | beta-adrenergic receptor kinase activity | import into cell | anatomical structure development | metabolic process | negative regulation of heart contraction | endocytosis | regulation of secretion | protein kinase activity | organic substance metabolic process | animal organ development | desensitization of G-protein coupled receptor protein signaling pathway | regulation of cell communication | negative regulation of signal transduction | signaling | negative regulation of the force of heart contraction by chemical signal | cellular protein metabolic process | receptor-mediated endocytosis | regulation of G-protein coupled receptor protein signaling pathway | kinase activity | developmental process | peptidyl-serine phosphorylation | cellular protein modification process | regulation of transport | receptor metabolic process | cardiac muscle contraction | cellular metabolic process | cellular response to organic substance | negative regulation of striated muscle contraction | circulatory system development | muscle system process | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

cell | cytoplasm | cell projection | plasma membrane | cilium | organelle | cell periphery | cytosol | intracellular | membrane