QuickView for GRK3;jsessionid=CFF4E6AFAB29FB0A301748A346B65437 (gene)
- Gene Symbol:
- GRK3
Homo sapiens - Full name:
- G protein-coupled receptor kinase 3
- Synonyms:
- ADRBK2, BARK2, beta-adrenergic receptor kinase 2, adrenergic, beta, receptor kinase 2, beta-ARK-2
- Genomic Location:
- Chr 22: 24290861-24455259
- Description:
-
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data sugg...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
22q12.1
GO Molecular Function
ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | G-protein coupled receptor kinase activity | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | beta-adrenergic receptor kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
establishment of localization | cellular process | localization | regulation of cellular process | response to stimulus | protein serine/threonine kinase activity | G-protein coupled receptor signaling pathway | protein modification process | macromolecule modification | G-protein coupled receptor kinase activity | nitrogen compound metabolic process | phosphorus metabolic process | vesicle-mediated transport | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | receptor internalization | protein metabolic process | beta-adrenergic receptor kinase activity | import into cell | metabolic process | endocytosis | protein kinase activity | organic substance metabolic process | signaling | cellular protein metabolic process | receptor-mediated endocytosis | kinase activity | cellular protein modification process | receptor metabolic process | cellular metabolic process | signal transduction | macromolecule metabolic process
GO Cellular Component
cell | cytoplasm | plasma membrane | cell periphery | cytosol | intracellular | membrane
