QuickView for GRN (gene)

Gene Symbol:

GRN Homo sapiens

Full name:

granulin precursor

Synonyms:

CLN11, GEP, GP88, PCDGF, PEPI, PGRN, granulins, PC cell-derived growth factor, acrogranin, granulin-epithelin, proepithelin, progranulin

Genomic Location:

Chr 17: 39778017-39785996

Description:

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin whic...

View Full Description

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TCANNTGAY_SREBP1_01 ,  GGGAGGRR_MAZ_Q6 ,  SREBP1_01 ,  SREBP_Q3 ,  CCANNAGRKGGC_UNKNOWN ,  STAT5A_01 ,  USF_02

Cytogenetic Map:

17q21.31

search → result