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QuickView for GSDMD (gene)


Gene Symbol:
GSDMD Homo sapiens Homo sapiens
Full name:
gasdermin D
Synonyms:
DF5L, DFNA5L, FKSG10, GSDMDC1, gasdermin-D, gasdermin domain containing 1, gasdermin domain-containing protein 1
Genomic Location:
Chr 8: 144711635-144716375
Description:
Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 8
8q24.3


Transcripts Names
NM_024736
NM_001166237
XM_011517301
Protein Names
A8K702
Q96Q98
D3DWJ9
P57764



GO Molecular Function

phosphatidylinositol-4,5-bisphosphate binding | modified amino acid binding | lipid binding | phospholipid binding | phosphatidylglycerol binding | anion binding | phosphatidylinositol bisphosphate binding | ion binding | protein binding | phosphatidylserine binding | phosphatidylinositol binding | phosphatidylinositol-4-phosphate binding | cardiolipin binding | phosphatidic acid binding | phosphatidylinositol phosphate binding

GO Biological Process

response to extracellular stimulus | protein homooligomerization | regulation of interleukin-1 beta production | exocytosis | neutrophil activation | regulation of localization | defense response to other organism | establishment of localization | defense response | cellular response to extracellular stimulus | positive regulation of interleukin-1 beta secretion | positive regulation of protein secretion | defense response to Gram-negative bacterium | cellular process | secretion | leukocyte degranulation | localization | interspecies interaction between organisms | regulation of cellular process | leukocyte activation | cellular component organization | regulation of peptide secretion | response to stimulus | positive regulation of interleukin-1 beta production | neutrophil degranulation | response to stress | leukocyte activation involved in immune response | programmed cell death | secretion by cell | positive regulation of cytokine secretion | membrane disruption in other organism | regulation of protein transport | cellular component assembly | regulation of peptide transport | positive regulation of peptide secretion | response to external biotic stimulus | protein complex oligomerization | leukocyte mediated immunity | pore formation in membrane of other organism | positive regulation of secretion | modification of morphology or physiology of other organism | vesicle-mediated transport | regulated exocytosis | positive regulation of interleukin-1 secretion | pore complex assembly | response to bacterium | regulation of interleukin-1 production | cell communication | positive regulation of interleukin-1 production | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | defense response to bacterium | positive regulation of establishment of protein localization | positive regulation of transport | regulation of cytokine secretion | protein-containing complex assembly | regulation of establishment of protein localization | regulation of interleukin-1 beta secretion | regulation of secretion | immune response | cell death | regulation of protein secretion | positive regulation of cytokine production | cell activation | positive regulation of protein transport | defense response to Gram-positive bacterium | regulation of cytokine production | response to biotic stimulus | regulation of transport | innate immune response | neutrophil mediated immunity | cytolysis | immune system process | regulation of protein localization | pyroptosis | response to other organism

GO Cellular Component

secretory granule | NLRP3 inflammasome complex | intracellular membrane-bounded organelle | tertiary granule | cytoplasmic vesicle | cell | nuclear lumen | inflammasome complex | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | ficolin-1-rich granule lumen | protein-containing complex | secretory vesicle | endomembrane system | nucleoplasm | plasma membrane | vesicle | specific granule | extracellular region | membrane-bounded organelle | specific granule lumen | nucleus | organelle | extracellular space | cell periphery | tertiary granule lumen | membrane-enclosed lumen | secretory granule lumen | cytosol | intracellular vesicle | intracellular | membrane | vesicle lumen