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QuickView for GUSB;jsessionid=C904969F2E611C570EE21C539E55C7CD (gene)

Gene Symbol:
GUSB Homo sapiens Homo sapiens
Full name:
glucuronidase beta
BG, MPS7, beta-glucuronidase, beta-D-glucuronidase, beta-G1
Genomic Location:
Chr 7: 65063106-65084681
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pse...
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Canis lupus familiaris Gallus gallus Pan troglodytes Bos taurus Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 7

GO Molecular Function

signaling receptor binding | hydrolase activity | hydrolase activity, hydrolyzing O-glycosyl compounds | catalytic activity | protein domain specific binding | hydrolase activity, acting on glycosyl bonds | beta-glucuronidase activity | carbohydrate binding | protein binding

GO Biological Process

exocytosis | neutrophil activation | establishment of localization | glucuronoside metabolic process | cellular process | secretion | organic substance catabolic process | leukocyte degranulation | localization | carbohydrate derivative catabolic process | glycosaminoglycan catabolic process | carbohydrate catabolic process | leukocyte activation | catabolic process | response to stimulus | neutrophil degranulation | carboxylic acid catabolic process | leukocyte activation involved in immune response | secretion by cell | nitrogen compound metabolic process | leukocyte mediated immunity | hyaluronan metabolic process | glycoside catabolic process | small molecule metabolic process | cellular carbohydrate metabolic process | cellular carbohydrate catabolic process | vesicle-mediated transport | regulated exocytosis | carbohydrate metabolic process | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | carboxylic acid metabolic process | metabolic process | glycoside metabolic process | immune response | organic substance metabolic process | cell activation | organonitrogen compound catabolic process | organic acid metabolic process | carbohydrate derivative metabolic process | glucuronoside catabolic process | neutrophil mediated immunity | immune system process | cellular metabolic process | hyaluronan catabolic process | glycosaminoglycan metabolic process | macromolecule metabolic process

GO Cellular Component

secretory granule | azurophil granule lumen | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | vacuolar lumen | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | ficolin-1-rich granule lumen | secretory vesicle | endomembrane system | vacuole | vesicle | extracellular exosome | lytic vacuole | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | lysosome | extracellular space | membrane-enclosed lumen | azurophil granule | lysosomal lumen | secretory granule lumen | intracellular vesicle | intracellular | membrane | vesicle lumen